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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source
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Controllability of Fuzzy Control Systems

IEEE Transactions on Systems, Man, and Cybernetics, 1986
Controllability properties of fuzzy dynamic systems are presented using graph representation. The indices of stability and controllability are introduced. A necessary condition for controllability is formulated. An algorithm for finding acceptable controls, based on a Lyapunov-like approach, is presented. A numerical example is given.
Madan M. Gupta   +2 more
openaire   +1 more source

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