Results 11 to 20 of about 8,292 (115)

Characterization of tumor mutation burden, PD-L1 and DNA repair genes to assess relationship to immune checkpoint inhibitors response in metastatic renal cell carcinoma

Journal for ImmunoTherapy of Cancer, 2020
Background Immune checkpoint inhibitors (ICIs) have expanded treatment options for metastatic renal cell carcinoma (mRCC); however, there are limited predictive biomarkers for response to ICIs in this indication, with programmed death-ligand 1 (PD-L1 ...
Rajan Gupta, Tian Zhang, Jason Zhu, Shannon McCall, James R White, Matthew Kyle Labriola, Jennifer Jackson, Eric F Kong, Gustavo Cerqueira, Kelly Gerding, John K Simmons, Daniel George   +11 more
doaj   +1 more source

How to Comply with the Paris Agreement Temperature Goal: Global Carbon Pricing According to Carbon Budgets

Energies, 2019
Avoiding irreversible climate change as effectively as possible is one of the most pressing challenges of society. Carbon pricing that is uniformly valid on a global and cross-sectoral basis represents a cost-efficient policy tool to meet this challenge.
Martin Zapf, Hermann Pengg, Christian Weindl   +2 more
doaj   +1 more source

Geographic regions with high prevalence of nonalcoholic steatohepatitis-related hepatic fibrosis are also observed to demonstrate high prevalence of metabolic disease risk factors and low consumption of fruits and vegetables

Clinical Nutrition Experimental, 2020
Summary: Background & aims: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease globally. We aim to evaluate prevalence and predictors of hepatic fibrosis among NAFLD patients, focusing on metabolic co-morbidities and ...
Robert J. Wong, Tram Tran, Harvey Kaufman, Justin Niles, Robert Gish   +4 more
doaj   +1 more source

Diagnostics of a Clamping Joint System

Journal of Mechanical Engineering, 2022
The article describes a diagnostic method, on the basis of which it is possible to assess whether there is a loose connection in the clamping system (detection) and to determine which of them is loose (localization).
Musil Miloš, Úradníček Juraj, Páleník Marek, Chlebo Ondrej   +3 more
doaj   +1 more source

Carotid Dolichoarteriopathy (Elongation) of the Carotid Arteries in Patients with Ischemic Stroke Anamnesis

Biomedicines, 2023
Carotid artery elongation (ECA) is widespread in the asymptomatic population and among people with a history of ischemic stroke (IS). There are different points of view on the ways these changes contribute to brain ischemic damage pathogenesis. Materials
Denis A. Golovin, Tatyana M. Rostovtseva, Yuri S. Kudryavtsev, Alexander B. Berdalin, Svetlana E. Lelyuk, Vladimir G. Lelyuk   +5 more
doaj   +1 more source

Understanding complexities in the uptake of indigenously developed rapid point-of-care diagnostics for containment of antimicrobial resistance in India

BMJ Global Health, 2021
A good point-of-care diagnostic test holds a promise to reduce inappropriate use of antibiotics by enabling early detection of the pathogen and facilitating rapid testing of antimicrobial susceptibility.
Raman R Gangakhedkar, Kamini Walia, Monica Sharma, Sanjay Bhattacharya   +3 more
doaj   +1 more source

Systemic mastocytosis – a diagnostic challenge

Revista Brasileira de Hematologia e Hemoterapia, 2014
Mastocytosis refers to a group of disorders characterized by the infiltration of clonally derived mast cells to the skin or extracutaneous tissues resulting in a heterogeneous clinical picture. It is a rare hematologic disorder in all its forms. The exact incidence is unknown; it affects patients of any age and males and females equally.
Lladó, AC, Mihon, C, Silva, M, Galzerano, A   +3 more
openaire   +4 more sources

Antibody Responses to BNT162b2 Vaccination in Japan: Monitoring Vaccine Efficacy by Measuring IgG Antibodies against the Receptor-Binding Domain of SARS-CoV-2

Microbiology Spectrum, 2022
To fight severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), mass vaccination has begun in many countries.
Hidetsugu Fujigaki, Yasuko Yamamoto, Takenao Koseki, Sumi Banno, Tatsuya Ando, Hiroyasu Ito, Takashi Fujita, Hiroyuki Naruse, Tadayoshi Hata, Saya Moriyama, Yoshimasa Takahashi, Tadaki Suzuki, Takahiro Murakami, Yukihiro Yoshida, Yo Yagura, Takayoshi Oyamada, Masao Takemura, Masashi Kondo, Mitsunaga Iwata, Kuniaki Saito   +19 more
doaj   +1 more source

ATM Immunohistochemistry as a Tool to Identify and Classify Somatic ATM Variants in Prostate Cancer

Journal of Molecular Pathology
Background/Objectives: Ataxia telangiectasia-mutated kinase is encoded by the ATM gene. This gene is altered in many cancer types; however, it is most relevant for eligibility of poly-ADP-ribose polymerase inhibitor (PARPi) therapy in metastatic castrate-
Roger Ferreira, Kassandra R. Bisson, Andrea Beharry, Champica Nicholas, Marco Iafolla, Samir Bidnur, Brandon S. Sheffield   +6 more
doaj   +1 more source

A CAN-Based Urea Line Heater Diagnostics Development and Experimental Validation for Selective Catalytic Reduction (SCR) System

IEEE Access, 2021
Urea line heating system is critical for Selective Catalytic Reduction (SCR) aftertreatment system under low temperature environment. Traditionally, the Electronic Control Unit (ECU) motivates urea lines heating command and diagnostics directly.
Lu Xie, Guozhang Jiang, Feng Qian
doaj   +1 more source