Results 71 to 80 of about 17,974,448 (292)
Dialysis access education in the United States: current status and ideas for the future
JVS-Vascular InsightsBackground: As of 2024, it is estimated that 37 million people in the United States suffer from chronic kidney disease, with 540,000 patients currently on dialysis. End-stage renal disease carries with it a mortality rate that is worse than most types of
Karl A. Illig, MD +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Acknowledgement to Reviewers of Diagnostics in 2017
, 2018 Peer review is an essential part in the publication process, ensuring that Diagnostics maintains high quality standards for its published papers.[...
Diagnostics Editorial Office
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Acknowledgement to Reviewers of Diagnostics in 2013
, 2014 The editors of Diagnostics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in ...
Diagnostics Editorial Office
core +1 more source
A Bayesian look at diagnostics in the univariate linear model [PDF]
, 1992 This paper develops diagnostics for data thought to be generated in accordance with the general univariate linear model. A first set of diagnostics is developed by considering posterior probabilities of models that dictate which of k observations form a ...
Guttman, Irwin, Peña, Daniel
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Announcement of the Diagnostics 2016 Junior Scientists Travel Award
, 2016 With the goal of recognizing outstanding contributions to the field of medical diagnostics by early-career investigators, including assistant professors, postdoctoral students and PhD students, and assisting them in attending international conferences in ...
Diagnostics Editorial Office
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source