Results 131 to 140 of about 24,380,822 (306)
Bayesian kernel-based system identification with quantized output data
, 2015 In this paper we introduce a novel method for linear system identification with quantized output data. We model the impulse response as a zero-mean Gaussian process whose covariance (kernel) is given by the recently proposed stable spline kernel, which ...
Hjalmarsson, Håkan, +5 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A survey on switched and piecewise affine system identification
, 2012 Recent years have witnessed a growing interest on system identification techniques for switched and piecewise affine models. These model classes have become popular not only due to the universal approximation properties of piecewise affine functions, but
Vicino, Antonio +2 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Continuous-time model identification for rotorcraft dynamics
, 2012 Accurate dynamic modelling of helicopter aeromechanics is becoming increasingly important, as progressively stringent requirements are being imposed on rotorcraft control systems.
M. Sguanci +2 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
MathematicsThis paper proposes a transition control strategy for a rotary double-inverted pendulum (RDIP) system using a sim-to-real reinforcement learning (RL) controller, built upon mathematical modeling and parameter estimation.
Doyoon Ju, Jongbeom Lee, Young Sam Lee
doaj +1 more source
, 2015 This paper is concerned with the problem of neural network identification and anti-disturbance control of a class of complex nonlinear systems with unknown exogenous disturbances and asymmetrical dead-zone constraints.
Yi, Yang, Zheng, Wei Xing (R8901)
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source