Results 271 to 280 of about 2,620,504 (318)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

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On robustness in system identification

Automatica, 1999
This paper studies robustness issues in system identification. A framework for robust convergence analysis is given. It uses a set of results on robust convergence under average \(l_p\) norms, Orlicz norms and cross-correlation-type noise semi-norms.
P. M. Mäkilä, Jonathan R. Partington
openaire   +1 more source

System identification with denoising

2000 IEEE International Conference on Acoustics, Speech, and Signal Processing. Proceedings (Cat. No.00CH37100), 2002
When the signal-to-noise ratio (SNR) is low, classical system identification methods can not produce accurate results. The results can be improved by using denoising methods with time-frequency decompositions. The chirp signal is used as a training sequence to make the time-frequency domain denoising possible.
Aykut Bultan, Richard A. Haddad
openaire   +1 more source

Secure system identification

2016 54th Annual Allerton Conference on Communication, Control, and Computing (Allerton), 2016
This work is concerned with the identification of linear time-invariant systems in the presence of an adversarial agent that attacks sensor measurements. The attacker is omniscient and we impose no restrictions (statistical or otherwise) on how the adversary alters the sensor measurements.
Mehrdad Showkatbakhsh, Paulo Tabuada, Suhas N. Diggavi   +2 more
openaire   +1 more source

Bayesian System Identification

IFAC Proceedings Volumes, 1979
Abstract In Bayesian statistics the concept of probability is interpreted as a rational measure of belief which is used to descri be mathemat ically the uncertain re lation between the statistician and the external world. The statistical inference is understood as a correction of prior subject ive probability distribution by objective data. The paper
openaire   +2 more sources

System theory for system identification

Journal of Econometrics, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

System Identification of Complex and Structured Systems

European Journal of Control, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Projectile identification system

32nd Applied Imagery Pattern Recognition Workshop, 2003. Proceedings., 2004
The U.S. Army plans for the needs of future warfare to retain its technological superiority. Future Combat Systems (FCS) is a major effort designed to meet this need. FCS includes multiple automated fire weapons. On current systems, a human typically enters information about each projectile loaded.
Glenn J. Beach, Charles J. Cohen, Gary Moody, Martha Henry   +3 more
openaire   +1 more source