Results 231 to 240 of about 2,250,860 (287)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Multiphysics Simulation for Efficient and Reliable Systems for Low-Temperature Plasma Treatment of Metals. [PDF]

Materials (Basel)
Penkova NY, Varhoshkov BE, Todorov V, Antchev H, Krumov K, Iliev V.   +5 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Integrating Computational Modelling into the Ecosystem of Cochlear Implantation: Advancing Access to Diagnostics, Decision-Making, and Post-Implantation Outcomes on a Global Scale. [PDF]

J Clin Med
Hanekom T.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Modelling Like an Experimentalist. [PDF]

Ecol Lett
Drake JM.
europepmc   +1 more source

Mechanobiological Regulation of Alveolar Bone Remodeling: A Finite Element Study and Molecular Pathway Interpretation. [PDF]

Biomolecules
Kuc AE, Sulewska M, Sybilski K, Kotuła J, Hajduk G, Saternus S, Małachowski J, Bar J, Lis J, Kawala B, Sarul M.   +10 more
europepmc   +1 more source

Editorial: Emerging methodologies in genotype-phenotype models for crop improvement. [PDF]

Front Plant Sci
Buck-Sorlin G, Xu L.
europepmc   +1 more source

Cost-Effectiveness Modelling of Multiple System Atrophy for Early Health Technology Assessment. [PDF]

Pharmacoecon Open
Grand TS, Ren S, Thokala P, Zanigni S, Åström DO, Bidani A, Höglinger G, Poewe W, Krismer F, Regnier S, EMSA-SG Natural History Study Investigators.   +10 more
europepmc   +1 more source

The involvement of stakeholders in computational model development to support decision-making in public health: a scoping review. [PDF]

BMC Public Health
Vriens M, Knoester OJ, Bosmans JE, Gabbert S, Ket JCF, de Wit GA, EVAneMENT study team.   +6 more
europepmc   +1 more source