Results 231 to 240 of about 18,821,561 (297)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Speaking of Opinions: Comparing Approaches to Modelling Opinion Manipulation. [PDF]

Mathematica (N Y)
Estrada L, Glendinning S, Nugent A.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Semantic modelling of animal welfare explained - Part 2: The basis of welfare weighting and usage of scientific information. [PDF]

Arch Anim Breed
Vonholdt-Wenker ML, Benthin J, Kauselmann K, Bracke MBM, Krause ET.   +4 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The impact of investments in health systems: a rapid review of computational models. [PDF]

BMJ Glob Health
Guzman-Tordecilla DN, Gupta S, Mabuchi S, Bornemisza O, Vecino-Ortiz AI.   +4 more
europepmc   +1 more source

In Silico Identification of Natural-Product Aromatase (CYP19A1) Inhibitors via Integrated Molecular Docking and QSAR Modelling. [PDF]

Bioinform Biol Insights
Akanko EA, Kporvie SS, Hanson G, Adu-Manu KS.   +3 more
europepmc   +1 more source

Semantic modelling of animal welfare explained - Part 1: Calculating overall welfare scores for husbandry systems using the ANyWEL model framework. [PDF]

Arch Anim Breed
Benthin J, Kauselmann K, Krause ET, Bracke MBM, Vonholdt-Wenker ML.   +4 more
europepmc   +1 more source

Dynamic models of occupational fatigue: a systematic review for risk management advancement. [PDF]

BMC Public Health
Wahyuni A, Russeng SS, Birawida AB, Amqam H, Rahman MA, Bakri I.   +5 more
europepmc   +1 more source

The eight pillars of within-host tuberculosis modelling. [PDF]

Front Immunol
Kaondera-Shava RF, Michael CT, Kirschner D, Bowness R.   +3 more
europepmc   +1 more source