Results 111 to 120 of about 170,074,763 (296)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Distance Metric Learning Techniques for the Performance Improvement of ML-kNN and Ranking-SVM-based Multi-label Pattern Classification

ASEAN Journal on Science and Technology for Development
A multi-label pattern classification system tries to predict the set of class labels of a test example by learning from the training examples with the relevant label sets.
Shajee Mohan B. S., Sneha S Mohan
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Food Labels: Implications for U.S. Agricultural Imports [PDF]

Labels have been used to make food attributes transparent and to satisfy the increasing consumer demand for information about food credence values. Several types of prevalent U.S.
Henneberry, Shida Rastegari, Mutondo, Joao E.   +1 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Deep-learning-based 3D content-based image retrieval system on chest HRCT: Performance assessment for interstitial lung diseases and usual interstitial pneumonia

European Journal of Radiology Open
Background: Diffuse parenchymal lung diseases have various conditions and CT imaging findings. Differentiating interstitial lung diseases (ILDs) and determining the presence or absence of usual interstitial pneumonia (UIP), can be challenging, even for ...
Akira Oosawa, Atsuko Kurosaki, Atsushi Miyamoto, Shigeo Hanada, Yuichiro Nei, Hiroshi Nakahama, Yui Takahashi, Takahiro Mitsumura, Hisashi Takaya, Tomohisa Baba, Tae Iwasawa, Masatoshi Hori, Shoji Kido, Takashi Ogura, Noriyuki Tomiyama, Kazuma Kishi, Meiyo Tamaoka   +16 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A System for Automatic, Quantitative and Visual Labeling for Failure Management in Cellular Network Data Clusters

IEEE Open Journal of the Communications Society
Cellular network operation strongly relies in the operator’s capacity to manage failures and optimize the networks for their efficient and proper functioning.
Javier Villegas, Sergio Fortes, Juan Cantizani-Estepa, Javier Albert-Smet, Raul Martin-Cuerdo, Raquel Barco   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source