Results 111 to 120 of about 404,025 (298)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Comment on Understanding PPPs and PPP Based National Accounts [PDF]
The paper discusses the three major problems that Deaton and Heston identify that make it difficult to construct consistent estimates of real output across countries: (i) the choice of a multilateral index number formula; (ii) weak national accounts ...
Diewert, Erwin
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Macro-SAMs for modelling purposes. An application to Portugal in 2003 [PDF]
Knowledge of the quantifiable side of a market economy greatly depends on the form of macro-economic modelling that is used. This, in turn, should have an underlying database.
Susana Santos
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
National Accounts 1990–1998 : Tables
, 1999 Uudistettu kansantalouden tilinpito Euroopan tilinpitojärjestelmän (EKT 1995) mukaisena National accounts revised according to the European System of Accounts (ESA 1995)Suomen virallinen tilasto ...
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Three centuries of macro-economic statistics
This paper describes the history of the national accounts starting from the incidental estimates by Petty, King and Davenant in the seventeenth century.
Bos, Frits
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Medical Savings Accounts in Singapore: How much is adequate? [PDF]
While many studies have examined the cost-containment aspect of Medical savings accounts (MSA), few have investigated the adequacy of MSA to finance the health care expenditure. This paper estimates the present value of lifetime healthcare expenses (PVHE)
Albert K C Tsui, Ngee-Choon Chia
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