Results 111 to 120 of about 588,710 (303)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Human Eye Visualization With an Attention Mechanism: Enhancing Flower Detection and Classification With Visual Attention and Photometric Principles Inspired by Human Vision

Engineering Reports
In this paper, a visual attention network (VANet) that draws inspiration from the complex workings of the human visual system is presented. The human eye possesses an extraordinary capacity to selectively concentrate on particular features within a scene
Arpan Singh, C. K. Yogesh, Christy Jackson Joshua   +2 more
doaj   +1 more source

Residual classes based mathematical model of the computer system's reliability

Procedia Computer Science, 2022
Victor Krasnobayev, Alexandr Kuznetsov, Yelyzaveta Kuznetsova, Roman Kochan, Tomasz Gancarczyk   +4 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A novel subsurface slopes hazardous mapping with engineering geologic and geophysical characterizations

Heliyon
Engineering geological characterizations, and geophysical mapping of subsurface structures to monitor some susceptible infrastructural facilities to hazardous slopes for effectiveness, safety to lives and properties, in addition to policy management for ...
Mohamad Anuri Ghazali, Mohd Rozi Umor, John Stephen Kayode, Abd Ghani Rafek, Mohd Hariri Arifin   +4 more
doaj   +1 more source

The method of statistical processing of data of RGB pixels of color images based on the system of residual classes

, 2023
Наталія Возна, Ihor Pitukh, Lydmula Hryha   +2 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Development and Testing of an AI-Based Specific Sound Detection System Integrated on a Fixed-Wing VTOL UAV

Acoustics
This study presents the development and validation of an AI-based system for detecting chainsaw sounds, integrated into a fixed-wing VTOL UAV. The system employs a convolutional neural network trained on log-mel spectrograms derived from four sound ...
Gabriel-Petre Badea, Mădălin Dombrovschi, Tiberius-Florian Frigioescu, Maria Căldărar, Daniel-Eugeniu Crunteanu   +4 more
doaj   +1 more source