Results 171 to 180 of about 18,382,058 (316)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

open access: yesAdvanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni   +17 more
wiley   +1 more source

Electrochemically Driven Regioselective Radical Functionalization of Allenes: Scope and Mechanistic Insights

open access: yesAdvanced Science, EarlyView.
Allenes emerge as powerful platforms for electrochemical functionalization through radical pathways. Selective radical addition at the central carbon triggers anodic oxidation and intramolecular cyclization, enabling efficient synthesis of oxazolines and oxazolidine‐2‐imines without external oxidants.
Pranjal Pyne   +5 more
wiley   +1 more source

Economic impacts of migration and population growth: position paper

open access: yes, 2006
Migration has been an important influence on Australian society and economy. Today, Australia has about 7 million more people due to migration since the Second World War.
Productivity Commission
core  

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

open access: yesAdvanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang   +9 more
wiley   +1 more source

Analysis of Productivity Measures and the Factors Affecting Accurate Measurement of Productivity

open access: yes, 2006
The purpose of the research has been to analyze the factors involved in the measurement of productivity at the plant level. The study was undertaken to determine the methods of measurement being used at the plant level and observe the accuracy of the ...
Sohail, Saqib Mian
core  

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

open access: yesAdvanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao   +8 more
wiley   +1 more source

New Zealand’s Productivity Growth: Component and Industry Decompositions

open access: yes, 2015
This note applies Diewert (2014a)’s productivity growth decomposition method to New Zealand data. This approach decomposes aggregate labour productivity growth into: industry labour productivity growth, changes in industry labour input shares and ...
Laws, Athene, Meehan, Lisa
core  

Products of Ordered Systems [PDF]

open access: yesProceedings of the American Mathematical Society, 1952
openaire   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

open access: yesAdvanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem   +24 more
wiley   +1 more source

Review of TCF Assistance [PDF]

open access: yes
The Commission was asked to evaluate current assistance arrangements to the TCF industries and provide policy options for post 2005 assistance and to report on a range of related matters that will affect the sector's long-term viability. The inquiry will
Productivity Commission
core  

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