Results 121 to 130 of about 3,181,399 (253)

Philippine Performance Evaluation and Assessment Scheme (PPEAS): Experiences in Newborn Screening System Quality Improvement. [PDF]

Int J Neonatal Screen, 2020
Padilla CD, Therrell BL, Panol KAR, Suarez RCN, Reyes MEL, Jomento CM, Maceda EBG, Lising JAC, Beltran FDE, Orbillo LL.   +9 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Behavioral determinants of continued use of Islamic FinTech: The moderating role of service and system quality. [PDF]

PLoS One
Alsmadi AA.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimizing adolescent HIV care: a review of EMR system quality for clinical monitoring in Zambia. [PDF]

Front Public Health
Moomba K, Van Wyk B.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Correction: Perceptions of healthcare finance and system quality among Nigerian healthcare workers. [PDF]

PLOS Glob Public Health
Josiah BO, Enebeli EC, Duncan BA, Anukam LU, Akingbade O, Ncube F, Josiah CC, Alimele EK, Otoboyor NL, Josiah OG, Mukoro JU, Nganwuchu BC, Opeyemi FI, Olaosebikan TW, Kantaris M.   +14 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Critical review of healthcare financing and a survey of system quality perception among healthcare users in Nigeria (2010-2023). [PDF]

PLOS Glob Public Health
Josiah BO, Enebeli EC, Duncan BA, Adejumo PO, Josiah CC, Anukam L, Shittu MB, Ncube F, Alimele KE, Emmanuel M, Martins-Ifeanyi OP, Opeyemi FI, Akingbade O, Adebayo AP, Ibraheem BM, Ekenekot UA, Edafiejire MS, Olukoya SO, Mukoro UJ, Baghdasarian S, Obialor JC, Alao GO, Obialor BO, Otoboyor NL, Josiah OG, Okonkwo J, Imoyera PE, Gbolabo AA, Nganwuchu BC, Oladimeji OJ, Olaosebikan TW, Kantaris M.   +31 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source