Results 91 to 100 of about 3,219,636 (303)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Crack Propagation Calculations for Optical Fibers under Static Bending and Tensile Loads Using Continuum Damage Mechanics

open access: yesSensors, 2017
Static fatigue behavior is the main failure mode of optical fibers applied in sensors. In this paper, a computational framework based on continuum damage mechanics (CDM) is presented to calculate the crack propagation process and failure time of optical ...
Yunxia Chen, Yuxuan Cui, Wenjun Gong
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

A Numerical Study on Influence of Temperature on Lubricant Film Characteristics of the Piston/Cylinder Interface in Axial Piston Pumps

open access: yesEnergies, 2018
The loss of kinetic energy of moving parts due to viscous friction of lubricant causes the reduction of piston pump efficiency. The viscosity of lubricant film is mainly affected by the thermal effect. In order to improve energy efficiency of piston pump,
Yueheng Song, Jiming Ma, Shengkui Zeng
doaj   +1 more source

Progressive Reliability Method and Its Application to Offshore Mooring Systems [PDF]

open access: yes, 2013
Assessing the reliability of complex systems (e.g. structures) is essential for a reliability-based optimal design that balances safety and costs of such systems.
Mousavi, Mir Emad   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Reliability of voting in fault-tolerant software systems for small output spaces [PDF]

open access: yes
Under a voting strategy in a fault-tolerant software system there is a difference between correctness and agreement. An independent N-version programming reliability model is proposed for treating small output spaces which distinguishes between ...
Mcallister, David F.   +2 more
core   +1 more source

Classes of Byzantine Fault-Tolerant Algorithms for Dependable Distributed Systems. [PDF]

open access: yes, 1998
This thesis concentrates on the design of new algorithms for fault-tolerant systems based on system-level hardware masking redundancy. It is argued that any system in which a reliability improvement of at least a factor 100 is required should be based on
Postma, André
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Wind turbine condition monitoring dataset of Fraunhofer LBF

open access: yesScientific Data
Fraunhofer wind turbine dataset contains monitoring data from a 750 W wind turbine, including accelerometers and tachometer, to capture structural response, bearing vibrations and rotational velocity.
Atabak Mostafavi, Andreas Friedmann
doaj   +1 more source

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