Evaluation Applied to Reliability Analysis of Reconfigurable, Highly Reliable, Fault-Tolerant, Computing Systems for Avionics [PDF]
Emulation techniques are proposed as a solution to a difficulty arising in the analysis of the reliability of highly reliable computer systems for future commercial aircraft.
Migneault, G. E.
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Data set for power system reliability analysis using a four-area test network. [PDF]
Data Brief, 2020 Sperstad IB +3 more
europepmc +1 more source
Reliability studies of integrated modular engine system designs [PDF]
A study was performed to evaluate the reliability of Integrated Modular Engine (IME) concepts. Comparisons were made between networked IME systems and non-networked discrete systems using expander cycle configurations.
Hardy, Terry L., Rapp, Douglas C.
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Efficient System Reliability-Based Design Optimization Study for Replaced Hip Prosthesis Using New Optimized Anisotropic Bone Formulations. [PDF]
Materials (Basel), 2020 Kharmanda G, Gowid S, Mahdi E, Shokry A.
europepmc +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
On the stress- and strain-based fatigue behavior of welded thick-walled nodular cast iron
Fracture and Structural IntegrityNodular cast iron (GJS) represents one of the most widely used materials for vehicle, energy and heavy machinery industry. Nevertheless, foundries struggling with the influence of local material defects in GJS like pores, shrinkages and dross often ...
Christoph Bleicher +3 more
doaj
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source