Results 51 to 60 of about 3,166,293 (279)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Probability Analysis of Hypertension-Related Symptoms Based on XGBoost and Clustering Algorithm
Applied Sciences, 2019 In this paper, cluster analysis and the XGBoost method are used to analyze the related symptoms of various types of young hypertensive patients, and finally guide patients to target treatment.
Wenbing Chang +6 more
doaj +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Progressive Reliability Method and Its Application to Offshore Mooring Systems [PDF]
, 2013 Assessing the reliability of complex systems (e.g. structures) is essential for a reliability-based optimal design that balances safety and costs of such systems.
Mousavi, Mir Emad +2 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
System reliability analysis through corona testing [PDF]
A corona vacuum test facility for nondestructive testing of power system components was built in the Reliability and Quality Engineering Test Laboratories at the NASA Lewis Research Center. The facility was developed to simulate operating temperature and
Koutnik, E. A. +2 more
core +2 more sources
Towards operational measures of computer security [PDF]
, 1993 Ideally, a measure of the security of a system should capture quantitatively the intuitive notion of ‘the ability of the system to resist attack’. That is, it should be operational, reflecting the degree to which the system can be expected to remain free
Brocklehurst, S. +8 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Uncertainty Evaluation in Multistage Assembly Process Based on Enhanced OOPN
Entropy, 2018 This study investigated the uncertainty of the multistage assembly process from the viewpoint of a stream of defects in the product assembly process. The vulnerable spots were analyzed and the fluctuations were controlled during this process.
Yubing Huang +3 more
doaj +1 more source