Results 61 to 70 of about 3,189,856 (298)

Progressive Reliability Method and Its Application to Offshore Mooring Systems [PDF]

, 2013
Assessing the reliability of complex systems (e.g. structures) is essential for a reliability-based optimal design that balances safety and costs of such systems.
Mousavi, Mir Emad, Gardoni, Paolo, Maadooliat, Mehdi   +2 more
core   +1 more source

System reliability analysis through corona testing [PDF]

A corona vacuum test facility for nondestructive testing of power system components was built in the Reliability and Quality Engineering Test Laboratories at the NASA Lewis Research Center. The facility was developed to simulate operating temperature and
Koutnik, E. A., Lalli, V. R., Mueller, L. A.   +2 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Analysis of the Anisotropic Cyclic Material Behavior of EN AW-1050A H24 Derived from Strain-Controlled Testing Using a Clip-On Extensometer and an Optical System

Crystals
Due to its good conductive properties, unalloyed (pure) aluminum, such as EN AW-1050A H24, finds new fields of application in electromobility. To optimize components, the cyclic material behavior must be understood and described precisely as a foundation
Tim Korschinsky, Benjamin Möller, Marvin Kiel, Matthias Hecht   +3 more
doaj   +1 more source

EPUAP classification system for pressure ulcers: European reliability study [PDF]

, 2007
‘The definitive version is available at www3.interscience.wiley.com .' Copyright Blackwell PublishingPeer ...
Bates-Jensen B.M, Bennett R.G., Black J., Bours G.J., Collier M., Dealey C., Derre B., Donnelly J., European Pressure Ulcer Advisory Panel (EPUAP), Fletcher J., Guggenmoos-Holzmann I., Maklebust J., National Pressure Ulcer Advisory Panel., Polit D.F., Russell L., Sharp A., Witkowski J.A., Wound, Ostomy, and Continence Nurses Society (WOCN)   +17 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Hybrid redundancy system for improving reliability - A concept [PDF]

, 1971
System combines two concepts - triple modular redundancy (TMR) and spares (replacement system) redundancy. System has triplicated active unit core with associated bank of specifically arranged standby spare units.
Mathur, F. P.
core   +1 more source

Reliability approach for safe designing on a locking system [PDF]

, 2010
The aim of this work is to predict the failure probability of a locking system. This failure probability is assessed using complementary methods: the First-Order Reliability Method (FORM) and Second-Order Reliability Method (SORM) as approximated methods,
ARNOUX, Philippe, DAU, Frédéric, GUILLAUMAT, Laurent, MEALIER, Nicolas   +3 more
core   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source