Results 41 to 50 of about 49,855 (230)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Research progress and prospects of seismic performance on underground structure embedded in soft soil foundation

Scientific Reports
For the complexity and difficulty of seismic research on subway station structure system embedded in soft soil foundation, the seismic research method is quite different from the ground structure.
Xuelei Cheng, Qiqi Li, Ran Hai, Shuoshuo Guo, Xiaofan Xing   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Prediction method for the reaction force of vehicle door sealing systems.

PLoS ONE
The accuracy of calculating the reaction force in vehicle sealing systems using moment equilibrium equations from statics is highly dependent on the degree of simplification in the mathematical model.
Zhong Yang, Luoxing Li, Jing Huang, Guoqing Chen, Zhengqing Liu, Zhenhu Wang   +5 more
doaj   +1 more source

Research on Nonlinear Dynamics Modeling and Simulation of Harmonic Gear Drive

Jixie chuandong, 2021
Due to the particularity of the structure，the hysteretic stiffness and dynamic friction belong to the inherent properties of harmonic gear drive. Traditional models consider the stiffness as a fixed stiffness or segmented stiffness model，and the friction
Yang Luo, Manyi Chen, Jie Zhang, Ran Yang, Han Zhang   +4 more
doaj  

Application Prospect and Simulation Verification of ATARI Carrier Landing [PDF]

Hangkong bingqi
To promote the application and development in the field of carrier-based aircraft landing, this paper analyzes a landing technology of the US Navy, namely Aircraft Terminal Approach Remote Inceptor (ATARI). By adopting research methods such as literature
Wang Jie, Han Wei, Yin Dawei, Wan Bing, Su Xichao
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Hydrodynamic Performance of Submerged Plates During Focused Waves

Journal of Marine Science and Engineering, 2019
Submerged horizontal plates are widely employed in research of wave structure interaction as a simplification of coastal and ocean engineering structures.
Qinghe Fang, Can Yang, Anxin Guo
doaj   +1 more source