Results 181 to 190 of about 12,410 (294)

Principles in Patterns (PiP) : User Acceptance Testing of Course and Class Approval Online Pilot (C-CAP)

, 2012
The PiP Evaluation Plan documents four distinct evaluative strands, the first of which entails an evaluation of the PiP system pilot (WP7:37 – Systems & tool evaluation).
Macgregor, George
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Comprehensive Self-Medication Management System to Reduce Medication Errors Among People Living With Dementia: Mixed Methods Feasibility and Usability Study. [PDF]

JMIR Hum Factors
Basapur S, Gellman C, Plenge JB, Troutman A, Yurko E, Woolsey B, McClendon J, Marceau L, Aggarwal NT.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Development and Psychometric Validation of a Usability Instrument Based on ISO 25010 for Electronic Health Record Systems in Peruvian Health Care Settings: Methodological Study. [PDF]

JMIR Hum Factors
Mamani-Pari D, Peñaloza-Hualpa AF, Humpiri-Flores ME, Gutierrez-Quispe E, Otazu-Luque JE.   +4 more
europepmc   +1 more source

EVALUASI USABILITY WEBSITE INFO KERJA DISNAKER KOTA PEKANBARU MENGGUNAKAN METODE SYSTEM USABILITY SCALE (SUS) [PDF]

ABSTRAK - Dinas Tenaga Kerja (Disnaker) merupakan instansi pemerintah yang bertugas memberikan layanan kepada masyarakat dibidang penyediaan jasa tenaga kerja, penempatan tenaga kerja, pelatihan, dan produktivitas kerja.
ANGGIT SEPTIANSYAH, Anggit, Medyantiwi Rahmawita Munzir, -   +1 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Evaluation of a Pilot Digital Antibiotic Tool. [PDF]

Clin Teach
Bowen J, Mollman J, Herchline D, Alex B, Pickering S, Girdwood ST.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multigesture Electromyographic Control Complexity in Upper Limb Prostheses Actuated via Single Sensor Input Contraction Magnitude: Qualitative Study for Evaluating Performance and Cognitive Load. [PDF]

JMIR Rehabil Assist Technol
Lalle A, Migliore S, Stevenson J, Bell E, Pradeep M, Gunnell D, Bennett S, Rivera V, Smith P, Dombrowski M, Sparkman J, Manero Ii A.   +11 more
europepmc   +1 more source