Results 121 to 130 of about 5,876,056 (368)

The impact of eHealth on the quality and safety of health care : a systematic overview [PDF]

, 2010
There is considerable international interest in exploiting the potential of digital solutions to enhance the quality and safety of health care. Implementations of transformative eHealth technologies are underway globally, often at very considerable cost.
Anandan, Chantelle, Black, Ashly D., Bokun, Tomislav, Car, Josip, Cresswell, Kathrin, Djulbegovic, Benjamin, Majeed, Azeem, McKinstry, Brian, Pagliari, Claudia, Procter, Rob, Sheikh, Aziz   +10 more
core   +6 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Efficacy of alternative seating on attention, in-seat behavior, and occupational performance in children with Attention Deficit Hyperactivity Disorder [PDF]

, 2019
Currently, there is one systematic review conducted by Gochenour and Poskey7 that synthesize current research evidence regarding alternative seating for students with attention difficulties. A limitation of this review, as noted by the authors, is a lack
Chacko, A., Kosztyo, K., Long, N., Mullan, Z., Norkitis, J., Potvin, PhD, OTR/L, M.-C., Wratcher, L.   +6 more
core   +1 more source

Challenges of systematic reviewing integrative health care. [PDF]

, 2013
This article is based on an extensive review of integrative medicine (IM) and integrative health care (IHC). Since there is no general agreement of what constitutes IM/IHC, several major problems were identified that make the review of work in this field
Coulter, Ian D, Crawford, Cindy, Hsiao, An-Fu, Khorsan, Raheleh   +3 more
core   +3 more sources

Treatment-resistant depression: A systematic review of systematic reviews

International Journal of Clinical and Health Psychology, 2014
AbstractThe objective of this research study was to assess pharmacological, somatic and/or psychological treatments in adults with a diagnosis of major depressive disorder who have not responded to at least one course of antidepressant medication. We conducted a systematic review to identify systematic scientific reviews and meta-analyses on treatment ...
Leticia Cuéllar-Pompa, Wenceslao Peñate-Castro, Juan Manuel Bethencourt-Pérez, Alia Inés Pérez-Wehbe, Lilisbeth Perestelo-Pérez   +4 more
openaire   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Predicting Outcomes From Radical Radiotherapy for Non-small Cell Lung Cancer: A Systematic Review of the Existing Literature

Frontiers in Oncology, 2018
Radical radiotherapy (RT) is a potentially curative treatment in non-small cell lung cancer (NSCLC) and is delivered in conventional 2-Gy fractions, hypofractionated and ablative stereotactic courses.
Gerard M. Walls, Gerard M. Walls, Gerard G. Hanna, Gerard G. Hanna, Fang Qi, Sai Zhao, Jun Xia, Mohammed T. Ansari, David Landau, David Landau   +9 more
doaj   +1 more source

Plain Tobacco Packaging: A Systematic Review [PDF]

, 2012
(From the Executive Summary): This systematic review outlines findings from 37 studies that provide evidence of the impacts of plain tobacco packaging.
Angus, Kathryn, Bauld, Linda, Hastings, Gerard, Hinds, Kate, Kwan, Irene, McNeill, Ann, Moodie, Crawford, O'Mara-Eves, Alison, Stead, Martine, Thomas, James   +9 more
core   +2 more sources

Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy [PDF]

, 2018
Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease.
A Klang, A Pakozdy, A Pakozdy, A Pakozdy, A Pellegrini, AD Quesnel, Akos Pakozdy, AM Wahle, AS Sawchuk, C Bertolani, CR Hooijmans, CW Dewey, D Hasegawa, D Hughes, D Moher, D Schwartz-Porsche, D Schwartz-Porsche, DB Roye, DE Cuff, DL Zoran, DM Boothe, DM Brewer, G Zaccara, G Zaccara, GE Solomon, GH Guyatt, H Volk, Holger A. Volk, JA Berlin, JA Wada, JAD Gasper, JM Ducote, KE Finnerty, KS Bailey, KS Bailey, LR Barnard, M Charalambous, M Charalambous, M Lowrie, M Podell, MA Cautela, MA Holmes, Marios Charalambous, MB Carnes, MJ Baho, NM van Gelder, O Engel, P Boydell, PN Papanikolaou, R Chou, S Cizinauskas, S Schriefl, S Wagner, SA Center, SD Ross, SF Bhatti, SM Cochrane, SM Cochrane, Sofie F. M. Bhatti   +58 more
core   +2 more sources