Results 171 to 180 of about 6,312,461 (358)

Safety of Radiofrequency Ablation of Benign Thyroid Nodules and Recurrent Thyroid Cancers: A Systematic Review and Meta-Analysis [PDF]

, 2017
Sae Rom Chung, Chong Hyun Suh, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee   +5 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.

, 2012
Matthew Thompson, Ann Van den Bruel, Jan Y. Verbakel, Monica Lakhanpaul, T Haj-Hassan, Richard Stevens, Henriëtte A. Moll, Frank Buntinx, Marjolein Y. Berger, Bert Aertgeerts, Rianne Oostenbrink, David Mant   +11 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The effect of fiscal policy on diet, obesity and chronic disease: a systematic review

, 2010
Anne Marie Thow, Stephen Jan, Stephen Leeder, Boyd Swinburn   +3 more
openalex   +1 more source

Influence of race/ethnicity on prevalence and presentation of endometriosis: a systematic review and meta‐analysis [PDF]

, 2019
Olga Bougie, Ma.I Yap, Lindsey Sikora, Teresa E. Flaxman, Sukhbir S. Singh   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

T2DM Self-Management via Smartphone Applications: A Systematic Review and Meta-Analysis

, 2016
Mingxuan Cui, Xueyan Wu, Jiangfeng Mao, Xi Wang, Min Nie   +4 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Commentary: High Intensity Physical Rehabilitation Later Than 24 h Post Stroke Is Beneficial in Patients: A Pilot Randomized Controlled Trial (RCT) Study in Mild to Moderate Ischemic Stroke

Frontiers in Neurology, 2020
Mari Nakao, Mari Nakao, Mari Nakao, Masahiro Banno, Masahiro Banno, Masahiro Banno, Yuki Kataoka, Yuki Kataoka, Yuki Kataoka, Yuki Kataoka, Shunsuke Taito, Shunsuke Taito   +11 more
doaj   +1 more source