Results 241 to 250 of about 6,173,935 (359)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Effectiveness of Public Health Interventions in Food Safety: A Systematic Review

, 1998
Monica Campbell, Charles Gardner, John J. M. Dwyer, Sandy Isaacs, Paul Krueger, Jane Ying   +5 more
openalex   +2 more sources

Systematic reviews [PDF]

, 1997
T. Lancaster
openalex   +1 more source

Economics of Task-Shifting in Surgery: A Systematic Review. [PDF]

Health Sci Rep
Oko CI, Ali B, Monahan M, Aborode AT, Okon J, Ayomoh F, Ugwu C, Ekwebene O, Oza S, Ibe A, Ifeanyichi M, Wei CR, Akilimali A.   +12 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Book Review: Systematic Reviews: Synthesis of Best Evidence for Health Care Decisions [PDF]

, 1998
Mark P. Okamoto
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The efficacy and safety of feverfew (Tanacetum partheniumL.): an update of a systematic review [PDF]

, 2000
E Ernst, MH Pittler
openalex   +1 more source

Frailty assessment utilization around the globe-a systematic review. [PDF]

J Frailty Aging
Gaston S, Billman E, Han L, Drover D.
europepmc   +1 more source