Results 231 to 240 of about 3,583,013 (282)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Balanced crystalloids versus saline for critically ill patients: an overview of systematic reviews. [PDF]

Crit Care Sci
Shin SW, Ribeiro MC, Sansoni TM, Vergueiro Neto F, Falcao ALE, Stamponi DDS.   +5 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Risk-of-bias assessment of vaccine effectiveness studies: a scoping review of systematic reviews. [PDF]

Epidemiol Infect
Davoodi Z, Laurie C, Tingley K, Skidmore B, Shaver N, Sundaram ME, Fell DB, Brouwers M, Sulis G.   +8 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The association between air pollution and hypertension: An umbrella review of systematic reviews and meta-analyses. [PDF]

iScience
Zhou H, Ruan Y, Xu G, Tung TH, Luo C.
europepmc   +1 more source

Salivary biomarkers in burning mouth syndrome: an umbrella review of systematic reviews. [PDF]

BMC Oral Health
Machete MV, Bouaita A, Blanco-Carrión A, López López J, Martín Carreras-Presas C, Mascarenhas P, Evangelista JG, Trancoso PF, Azul AM, Zagalo C.   +9 more
europepmc   +1 more source

Laparoscopic versus robotic surgery for colorectal cancer: an updated meta-analysis with comparison against published systematic reviews. [PDF]

J Robot Surg
Han Y, Sha L.
europepmc   +1 more source

Mechanisms of Engagement With Mobile Health Apps for Adults With Long-Term Conditions: Overview of Systematic Reviews. [PDF]

JMIR Mhealth Uhealth
Baykoca J, Hurtado Barbeito G, Pearce CJ, Milne-Ives M, Hudson J, Norton S, Moss-Morris R.   +6 more
europepmc   +1 more source