Results 181 to 190 of about 13,028,724 (400)
Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceAlcohol Consumption and Risk of Fractures: A Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies
, 2023 Yamin Ke, Huifang Hu, Jinli Zhang, Lijun Yuan, Tian-Ze Li, Yifei Feng, Yuying Wu, Xueru Fu, Mengmeng Wang, Yajuan Gao, Weifeng Huo, Yaobing Chen, Wenkai Zhang, Longkang Wang, Xi Li, Jinyuan Pang, Zeqiang Zheng, Fulan Hu, Ming Zhang, Liang Sun, Yang Zhao, Jie Lu, Dongsheng Hu +22 moreopenalex +1 more sourcePredictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more sourceGlobal, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
The Lancet, 2016 M. Forouzanfar, A. Afshin, Lily T Alexander, H. R. Anderson, Z. Bhutta, S. Biryukov, M. Brauer, R. Burnett, Kelly M. Cercy, F. Charlson, A. Cohen, L. Dandona, Kara Estep, A. Ferrari, J. Frostad, N. Fullman, P. Gething, W. Godwin, Max G Griswold, Simon Iain Hay, Y. Kinfu, H. Kyu, H. Larson, Xiaofeng Liang, Stephen S. Lim, Patrick Y. Liu, Alan D. Lopez, R. Lozano, L. Marczak, G. Mensah, A. Mokdad, M. Moradi-Lakeh, M. Naghavi, B. Neal, M. Reitsma, Gregory A. Roth, J. Salomon, P. Sur, T. Vos, Joseph A Wagner, Haidong Wang, Yi Zhao, Maigeng Zhou, Gunn Marit Aasvang, A. Abajobir, K. H. Abate, C. Abbafati, K. Abbas, F. Abd-Allah, A. Abdulle, S. Abera, Biju Abraham, L. Abu-Raddad, G. Abyu, A. Adebiyi, I. Adedeji, Z. Ademi, A. K. Adou, J. Adsuar, E. Agardh, A. Agarwal, Anurag Agrawal, A. Kiadaliri, O. Ajala, T. Akinyemiju, Z. Al-Aly, K. Alam, N. Alam, S. Aldhahri, R. Aldridge, Z. A. Alemu, R. Ali, A. Alkerwi, F. Alla, P. Allebeck, U. Alsharif, K. Altirkawi, E. A. Martin, N. Alvis-Guzmán, Azmeraw T. Amare, A. Amberbir, A. Amegah, H. Amini, W. Ammar, Stephen M. Amrock, H. Andersen, B. Anderson, C. Antonio, P. Anwari, J. Ärnlöv, A. Artaman, H. Asayesh, R. Asghar, Reza Assadi, S. Atique, Euripide Avokpaho, A. Awasthi, B. Quintanilla, P. Azzopardi, U. Bacha, A. Badawi, M. Bahit, K. Balakrishnan, A. Barać, Ryan Barber, S. Barker-Collo, T. Bärnighausen, S. Barquera, L. Barregard, L. Barrero, S. Basu, C. Batis, S. Bazargan-Hejazi, J. Beardsley, Neeraj Bedi, E. Beghi, B. Bell, M. Bell, A. Bello, D. Bennett, I. Benseñor, A. Berhane, E. Bernabé, B. Betsu, A. Beyene, N. Bhala, A. Bhansali, S. Bhatt, S. Biadgilign, B. Bikbov, D. Bisanzio, E. Bjertness, J. Blore, R. Borschmann, S. Boufous, R. Bourne, M. Brainin, A. Brazinova, N. Breitborde, H. Brenner, D. Broday, T. Brugha, B. Brunekreef, Z. Butt, L. Cahill, Bianca Calabria, Ismael Campos-Nonato, Rosario Cárdenas, D. Carpenter, J. Carrero, Daniel C. Casey, C. Castañeda-Orjuela, Jacqueline Castillo Rivas, R. Castro, F. Catalá-López, Jung-Chen Chang, P. Chiang, Mirriam Chibalabala, Odgerel Chimed-Ochir, V. Chisumpa, Abdulaal Chitheer, J. Choi, H. Christensen, D. Christopher, Liliana G. Ciobanu, M. Coates, Samantha M. Colquhoun, A. C. Manzano, Leslie T. Cooper, Kimberly Cooperrider, Leslie Cornaby, Monica Cortinovis, J. Crump, L. Cuevas-Nasu, A. Damasceno, R. Dandona, S. Darby, P. Dargan, J. D. das Neves, A. Davis, K. Davletov, E. F. de Castro, Vanessa De la Cruz-Góngora, D. de Leo, L. Degenhardt, Liana C. Del Gobbo, B. del Pozo-Cruz, R. Dellavalle, A. Deribew, D. Jarlais, S. Dharmaratne, P. Dhillon, C. Díaz-Torné, D. Dicker, E. Ding, E. Dorsey, Kerrie E. Doyle, T. Driscoll, L. Duan, M. Dubey, B. Duncan, I. Elyazar, A. Endries, S. Ermakov, H. Erskine, B. Eshrati, A. Esteghamati, S. Fahimi, E. J. Faraon, T. Farid, C. Farinha, Andre Faro, M. Farvid, F. Farzadfar, V. Feigin, S. Fereshtehnejad, J. Fernandes, F. Fischer, J. Fitchett, T. Fleming, N. Foigt, Kyle Foreman, F. Fowkes, R. Franklin, Thomas Fürst, N. Futran, E. Gakidou, A. García-Basteiro, T. Gebrehiwot, A. Gebremedhin, J. Geleijnse, B. Gessner, A. Z. Giref, M. Giroud, Melkamu Dedefo Gishu, G. Giussani, S. Goenka, M. Gómez-Cabrera, H. Gómez-Dantés, P. Gona, A. Goodridge, S. Gopalani, C. Gotay, A. Goto, H. Gouda, H. Gugnani, F. Guillemin, Yuming Guo, Rahul Gupta, Rajeev Gupta, R. A. Gutiérrez, J. Haagsma, N. Hafezi-Nejad, D. Haile, G. B. Hailu, Y. Halasa, R. Hamadeh, S. Hamidi, A. Handal, G. Hankey, Y. Hao, H. Harb, S. Harikrishnan, J. Haro, Mohammad Sadegh Hassanvand, T. A. Hassen, Rasmus J. Havmoeller, I. Heredia-Pi, N. Hernández-Llanes, P. Heydarpour, H. Hoek, H. Hoffman, M. Horino, N. Horita, H. Hosgood, D. Hoy, M. Hsairi, A. Htet, G. Hu, John J Emmanuel Huang, A. Husseini, S. Hutchings, I. Huybrechts, K. Iburg, B. Idrisov, B. Ileanu, M. Inoue, T. Jacobs, K. Jacobsen, N. Jahanmehr, M. Jakovljevic, H. Jansen, S. Jassal, Mehdi Javanbakht, S. Jayaraman, A. Jayatilleke, S. Jee, P. Jeemon, V. Jha, Ying Jiang, T. Jibat, Ye Jin, C. Johnson, J. Jonas, Z. Kabir, Y. Kalkonde, R. Kamal, H. Kan, A. Karch, C. Karema, Chante Karimkhani, A. Kasaeian, Anil Kaul, N. Kawakami, Dhruv S. Kazi, P. Keiyoro, L. Kemmer, A. Kemp, A. Kengne, A. Keren, C. Kesavachandran, Y. Khader, Abdur Rahman Khan, E. Khan, G. Khan, Y. Khang, S. Khatibzadeh, S. Khera, T. Khoja, J. Khubchandani, C. Kieling, Cho-il Kim, Daniel H. Kim, R. Kimokoti, N. Kissoon, M. Kivipelto, L. Knibbs, Y. Kokubo, J. Kopec, P. Koul, A. Koyanagi, M. Kravchenko, H. Kromhout, H. Krueger, Tiffany Ku, B. K. Defo, R. Kuchenbecker, B. K. Bicer, E. Kuipers, G. Kumar, G. Kwan, D. Lal, R. Lalloo, T. Lallukka, Q. Lan, A. Larsson, A. Latif, A. Lawrynowicz, J. Leasher, J. Leigh, J. Leung, M. Levi, Xiaohong Li, Yichong Li, Juan Liang, Shiwei Liu, B. Lloyd, G. Logroscino, P. Lotufo, R. Lunevicius, Michael F. MacIntyre, M. Mahdavi, M. Majdan, A. Majeed, R. Malekzadeh, D. Malta, Wondimu Ayele Ayele Manamo, C. Mapoma, W. Marcenes, R. Martin, J. Martínez-Raga, F. Masiye, K. Matsushita, R. Matzopoulos, B. Mayosi, J. Mcgrath, M. Mckee, P. Meaney, C. Medina, A. Mehari, Fabiola Mejía-Rodríguez, A. Mekonnen, Y. Melaku, Z. Memish, W. Mendoza, Gert B. M. Mensink, A. Meretoja, T. Meretoja, Y. Mesfin, F. Mhimbira, Anoushka I Millear, T. Miller, E. Mills, M. Mirarefin, A. Misganaw, C. Mock, A. Mohammadi, S. Mohammed, G. Mola, L. Monasta, J. M. Hernandez, M. Montico, L. Morawska, R. Mori, D. Mozaffarian, U. Mueller, Erin C. Mullany, J. Mumford, G. Murthy, J. Nachega, A. Naheed, V. Nangia, N. Nassiri, J. Newton, Marie Ng, Q. Nguyen, M. I. Nisar, P. M. N. Pete, O. Norheim, Rosana E Norman, B. Norrving, L. Nyakarahuka, C. Obermeyer, F. Ogbo, I. Oh, Olanrewaju Oladimeji, Pedro R Olivares, H. Olsen, B. Olusanya, J. Olusanya, John Nelson Opio, Eyal Oren, R. Orozco, Alberto Ortiz, E. Ota, Mahesh Pa, A. Pana, Eun‐Kee Park, C. Parry, M. Parsaeian, Tejas Patel, A. P. Caicedo, Snehal T. Patil, S. Patten, G. Patton, N. Pearce, David M Pereira, N. Perico, K. Pesudovs, M. Petzold, M. Phillips, F. Piel, J. Pillay, D. Plass, S. Polinder, C. Pond, C. Pope, D. Pope, S. Popova, R. Poulton, F. Pourmalek, N. Prasad, M. Qorbani, Rynaz Rabiee, A. Radfar, Anwar Rafay, V. Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, S. Rahman, R. Rai, Sasa Rajsic, M. Raju, U. Ram, S. Rana, K. Ranganathan, P. Rao, Christian García, A. Refaat, C. Rehm, J. Rehm, Nikolas Reinig, G. Remuzzi, S. Resnikoff, A. Ribeiro, J. Rivera, H. S. Roba, Alina Rodriguez, S. Rodríguez-Ramírez, D. Rojas-Rueda +499 moresemanticscholar +1 more sourceFeasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more source
