Results 141 to 150 of about 1,671,144 (278)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Optimizing Prostate Biopsy Pathways: Integrating MRI-Targeted, Systematic Sampling, and Clinical Judgment in the PSA-Era. [PDF]

Diagnostics (Basel)
Bulai CA, Stoica RA, Militaru A, Punga AMA, Vaduva RI, Multescu RD, Mares C, Ene CV, Geavlete BF.   +8 more
europepmc   +1 more source

Systematic sampling of adults as a sensitive means of detecting persistence of lymphatic filariasis following mass drug administration in Sri Lanka. [PDF]

PLoS Negl Trop Dis, 2019
Rao RU, Samarasekera SD, Nagodavithana KC, Punchihewa MW, Ranasinghe USB, Weil GJ.   +5 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Physiochemical Properties of Soil from Waste Dumpsites within Choba, Alakahia and Rumuosi Communities in Akpor, Rivers State, Nigeria

Journal of Applied Sciences and Environmental Management
The objective of this paper was to evaluate the physicochemical properties of soil from solid waste dumpsites within Choba, Alakahia and Rumuosi in Akpor, Rivers State, Nigeria using a standard analytical methods.
N. Amadi, M. Yabrade, O. H. Nsan-Nicholas, V. L. Gbosidom   +3 more
doaj  

Transperineal MRI-US Fusion-Guided Biopsy with Systematic Sampling for Prostate Cancer: Diagnostic Accuracy and Clinical Implications Across PI-RADS. [PDF]

Cancers (Basel)
Richart V, Costa M, Muní M, Asiain I, Salvador R, Puig J, Rodriguez-Carunchio L, Salinas B, Comas-Cufí M, Nicolau C.   +9 more
europepmc   +1 more source

On Splitting Training and Validation Set: A Comparative Study of Cross-Validation, Bootstrap and Systematic Sampling for Estimating the Generalization Performance of Supervised Learning. [PDF]

J Anal Test, 2018
Xu Y, Goodacre R.
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

SyS3DS: Systematic Sampling of Large-Scale LiDAR Point Clouds for Semantic Segmentation in Forestry Robotics. [PDF]

Sensors (Basel)
Mukhandi H, Ferreira JF, Peixoto P.
europepmc   +1 more source