Results 191 to 200 of about 435,760 (256)

Particulate Matter concentration measurement in ambient air: analysis of filter material and recovery time variables for uncertainty assessment. [PDF]

Environ Monit Assess
Raso L, Rocca MRD, Belgiorno V, Naddeo V, Zarra T.   +4 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Maternal Oral Microbiome Dysbiosis and Adverse Pregnancy Outcomes: Microbial Signatures, Inflammatory Pathways, and Clinical Evidence. [PDF]

J Clin Med
Radu EA, Mocanu E, Fulina M, Rotar V, Enache F, Popescu S, Șerbănescu L.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Prevalence and Correlates of Test Anxiety Among Medical Students: Systematic Review. [PDF]

Adv Med Educ Pract
Mady MM, El Nayal M, Abdel-Khalek AM, Khan NS, Osman S, Sayegh MG, Hajomer HAE.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circadian clock regulation of hemostasis: a systematic review of molecular pathways. [PDF]

Res Pract Thromb Haemost
Ibrahim Z, Murphy RP, Guillaume GC, Arya R, Goswami N.   +4 more
europepmc   +1 more source

Exploring the conformational landscape of adenylate kinase and beyond with protein folding models. [PDF]

Sci Rep
Bhasin A, Delaunay A, Saccon F, Fu Y.
europepmc   +1 more source

Distance-Restraint-Guided Diffusion Models for Sampling Protein Conformational Changes and Ligand Dissociation Pathways. [PDF]

J Chem Theory Comput
Hori T, Moriwaki Y, Ishitani R.
europepmc   +1 more source

Surveys in clinical research: methodological aspects and practical guidance. [PDF]

Crit Care Sci
Bianchini L, Pereira AB, Tomazini BM, Righy C, Maia IS, Ramos JGR, Rosa RG, Roepke RML, Ferreira JC, Besen BAMP.   +9 more
europepmc   +1 more source