Results 241 to 250 of about 469,724 (303)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of pharmacist intervention on therapeutic drug monitoring of vancomycin: a meta-analysis. [PDF]

Front Pharmacol
Ma M, Cao D, Pan Y, Xiao G.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The burden of sarcopenia in people living with HIV: a systematic review and meta-analysis across WHO regions. [PDF]

BMC Infect Dis
Shrivastav VN, Makwana MN, Shah DP, Surti ZN.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Perspective of People Living With HIV and Healthcare Workers on the Uptake, Barriers, and Benefits of Multimonth Dispensing: A Qualitative Systematic Review. [PDF]

AIDS Res Treat
Okezie CW, Badru OA, Ibitoye FA, Edeh JC, Adeagbo OA.   +4 more
europepmc   +1 more source

Prevalence of De Quervain's Tenosynovitis among Mobile Phone Using Students in Pakistan: A Systematic Review and Meta-Analysis. [PDF]

Environ Health Insights
Bezie AE, Keleb A, Worku Jemil H, Adane KC.   +3 more
europepmc   +1 more source

N1 Staging in Non-Small Cell Lung Cancer: Current Situation, Limitations, and the Importance of Peripheral Nodal Assessment. [PDF]

Cancers (Basel)
Ishiwata T.
europepmc   +1 more source

Application Value of Radiomics-Based Machine Learning for Preoperative Risk Stratification of Bladder Cancer: Systematic Review and Meta-Analysis. [PDF]

J Med Internet Res
He Z, Liu Y, Jiang Q, Hou F, Xu B.
europepmc   +1 more source

How to optimally allocate sampling effort in experimental ecology. [PDF]

Sci Rep
Schweiger AH, Garthen A, Bahn M, Chalcraft D, Schtickzelle N, Larsen KS, Kreyling J.   +6 more
europepmc   +1 more source