Results 311 to 320 of about 9,132,693 (375)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

TABLE 8 in Odonata of the Kampar Peninsula: the first systematic survey of Odonata in Peat Swamp Forest in Sumatra

Rory A. Dow, Novia Gesriantuti, Muhammad Iqbal, Pungki Lupiyan-Ingdyah, JOHN F. PERIERA, Shinta O. Zulya, Bradford M. Sanders   +6 more
openalex   +1 more source

TABLE 6 in Odonata of the Kampar Peninsula: the first systematic survey of Odonata in Peat Swamp Forest in Sumatra

Rory A. Dow, Novia Gesriantuti, Muhammad Iqbal, Pungki Lupiyan-Ingdyah, JOHN F. PERIERA, Shinta O. Zulya, Bradford M. Sanders   +6 more
openalex   +1 more source

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Exploring Blockchains Interoperability: A Systematic Survey

ACM Computing Surveys, 2023
The next-generation blockchain ecosystem is expected to integrate both homogeneous and heterogeneous distributed ledgers. These systems require operations across multiple blockchains to enrich advanced functionalities for future applications.
G. Wang, Qin Wang, Shiping Chen
semanticscholar   +2 more sources

Systematic Survey

Encyclopedic Dictionary of Archaeology, 2021

semanticscholar   +2 more sources

A Systematic Survey of Just-in-Time Software Defect Prediction

ACM Computing Surveys, 2022
Recent years have experienced sustained focus in research on software defect prediction that aims to predict the likelihood of software defects. Moreover, with the increased interest in continuous deployment, a variant of software defect prediction ...
Yunhua Zhao, Kostadin Damevski, Hui Chen
semanticscholar   +1 more source

Recent advances in deep learning based dialogue systems: a systematic survey

Artificial Intelligence Review, 2021
Dialogue systems are a popular natural language processing (NLP) task as it is promising in real-life applications. It is also a complicated task since many NLP tasks deserving study are involved.
Jinjie Ni, Tom Young, Vlad Pandelea, Fuzhao Xue, V. Adiga, E. Cambria   +5 more
semanticscholar   +1 more source