Results 91 to 100 of about 435,673 (289)

FMO1 Is Involved in Excess Light Stress-Induced Signal Transduction and Cell Death Signaling

Cells, 2020
Because of their sessile nature, plants evolved integrated defense and acclimation mechanisms to simultaneously cope with adverse biotic and abiotic conditions.
Weronika Czarnocka, Yosef Fichman, Maciej Bernacki, Elżbieta Różańska, Izabela Sańko-Sawczenko, Ron Mittler, Stanisław Karpiński   +6 more
doaj   +1 more source

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer [PDF]

, 2016
Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation.
Chater, E, De Bruin, E, Downward, J, Heynen, GJJE, Hu, Y, Li, H, Liu, Z, Pardo, OE, Roy, R, Seckl, MJS, Smit, EF, Stokes, W, Tang, H, Wang, Y   +13 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Systemic acquired resistance, NPR1, and pathogenesis-related genes in wheat and barley

Journal of Integrative Agriculture, 2018
In Arabidopsis, systemic acquired resistance (SAR) is established beyond the initial infection by a pathogen or is directly induced by treatment with salicylic acid (SA) or its functional analogs, 2,6-dichloroisonicotinic acid (INA) and benzothiadiazole (
Xiao-dong WANG, Wei-shuai BI, Jing GAO, Xiu-mei YU, Hai-yan WANG, Da-qun LIU   +5 more
doaj   +1 more source

Exploring plant tolerance to biotic and abiotic stresses [PDF]

, 2007
Plants are exposed to many stress factors, such as drought, high salinity or pathogens, which reduce the yield of the cultivated plants or affect the quality of the harvested products. Arabidopsis thaliana was used as a model plant to study the responses
Karim, Sazzad
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Molecular studies of Arabidopsis and Brassica with focus on resistance to Leptosphaeria maculans [PDF]

, 2001
Blackleg caused by Leptosphaeria maculans is a widespread fungal disease on B~assica napus (oilseed rape). In contrast, Arabidopsis thaliana and B. nigra are in general highly resistant. This study presents results from genomic interaction between the A.
Bohman, Svante
core  

Clinical aspects of glucocorticoid sensitivity [PDF]

, 1996
Recent studies demonstrate that primary (hereditary) abnormalities in the glucocorticoid receptor gene make 6.6% of the normal population relatively 'hypersensitive' to glucocorticoids, while 2.3% are relatively 'resistant.' These abnormalities might ...
Huizenga, N.A.T.M. (Nannette), Jong, F.H. (Frank) de, Koper, J.W. (Jan), Lamberts, S.W.J. (Steven), Lange, P. (Pieter) de   +4 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Principles of Periodontology [PDF]

, 2013
Periodontal diseases are among the most common diseases affecting humans. Dental biofilm is a contributor to the etiology of most periodontal diseases.
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core   +2 more sources