Results 61 to 70 of about 100,804 (312)

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

DIAGNOSIS CRISIS IN THE BANKING SYSTEM

Financial and credit activity: problems of theory and practice, 2016
В статті визначено сутність діагностики як складової механізму державного антикризового регулювання банківської системи. Визначено, що об’єктами діагностики є мікрорівень (рівень окремих елементів банківської системи) та макрорівень (рівень банківської системи).
Kachala, T. M., Stadnyk, A. S.
openaire   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

LEGAL ASPECTS OF THE EUROPEAN BANKING UNION FORMATION

Московский журнал международного права, 2018
Introduction. The article is devoted to the development of banking regulation in the European Union, which subsequently led to the creation in 2012 of the European Banking Union as part of the Economic and Monetary Union. This process took place in three
E. B. Osokina
doaj   +1 more source

Interconnectedness between shadow and traditional banking systems in Europe [PDF]

Bankarstvo, 2017
The financial crisis that emerged in the US quickly spread across Europe, causing a severe banking and sovereign debt crisis. That revealed the importance of short-term financing for traditional banks, which increased their exposure to the financial ...
Popović Svetlana, Janković Irena, Lukić Velimir   +2 more
doaj   +1 more source

SYSTEMIC BANKING CRISIS AND MACROECONOMIC LEADING INDICATORS

Proceedings of the 28th International Academic Conference, Tel Aviv, 2017
The purpose of this study is to identify leading macroeconomic indicators causing or coinciding with systemic banking crises. The clear focus on systemic banking crisis leave little ambiguity of what constitutes a banking crisis. The macroeconomic leading indicators are chosen with economic theory in mind.
openaire   +2 more sources

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Inside the crisis: An empirical analysis of banking systems in distress [PDF]

Journal of International Money and Finance, 2000
Using aggregate and bank level data for several countries, the paper studies what happens to the banking system in the aftermath of a banking crisis. Contemporary crises are not accompanied by declines in aggregate bank deposits, and credit does not fall relative to output, although the growth of both deposits and credit slows down substantially ...
Poonam Gupta, Asli Demirgüç-Kunt, Enrica Detragiache   +2 more
openaire   +2 more sources

The Interconnections Between the Shadow Banking System and the Regular Banking System. Evidence from the Euro Area [PDF]

, 2013
One of the most important lessons of the global financial crisis has been the deep interconnectedness between the shadow banking system and the regular banking system.
Baicu, C., Jeffers, E.
core   +2 more sources