Results 71 to 80 of about 100,804 (312)

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

The real stabilisation plan and the banking sector in Brazil

PSL Quarterly Review, 1998
The performance of the Brazilian banking industry after price stabilisation and threat of a systemic crisis is evaluated. A theoretical approach to banking crisis as a possible result of credit expansion is developed.
F.J. CARDIM DE CARVALHO
doaj  

Moral hazard and the financial crisis of 2007-9: An Explanation for why the subprime mortgage defaults and the housing market collapse produced a financial crisis that was more severe than any previous crashes (with exception of the Great Depression of 1929) [PDF]

This paper examines the financial crisis in 2007-9 that was more severe than previous crashes, including the dot-com crash of 2001 and the market crash of 1987 (with the exception of the Great Depression of 1929).
Ronald Jean Degen
core  

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Shadow banking and its role in financial markets [PDF]

Anali Ekonomskog fakulteta u Subotici, 2017
The paper analyses the shadow banking system, its main participants, activities and associated risks. Shadow banking represents predominantly non-bank financial institutions' activities in credit risk transfer and liquidity and maturity transformation of
Janković Irena, Lukić Velimir, Popović Svetlana   +2 more
doaj  

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Fund Management and Systemic Risk - Lessons from the Global Financial Crisis [PDF]

, 2013
Fund managers play an important role in increasing efficiency and stability in financial markets. But research also indicates that fund management in certain circumstances may contribute to the buildup of systemic risk and severity of financial crises ...
Allen, Andersen, Aragon, Baba, BCBS, Bengtsson, Bengtsson, Bernanke, Bikhchandani, BIS, Borio, Borio, Brunnermeier, Buttonwood, CESR, Chan-Lau, Christoffersen, Cobley, Cole, Crane Data Archives, Crouchy, CSSF, Davis, Davis, Davis, Delbecque, Diamond, Dierick, Duffie, Duffie, Duygan-Bump, Dwyer, Edwards, Elsas, European Commission, European Parliament and Council of the European Union, Fender, Financial Stability Oversight Council, FSB, Garbaravicius, Gorton, Greene, Gunnarsdottir, IMF, Kahan, Kessler, Kiff, Kindleberger, King, Klapper, Kroszner, Lelyveld, Lescrauwaet, Lipper, Lyon, Martin, McCabe, Mezzacapo, Miles, Minsky, O'Kane, OECD, Olson, Pennacchi, Persaud, Rajan, Rochet, Rule, Santomero, Schich, Schmidt, Schultes, Shleifer, Standard & Poor's, Stecklow, Stigum, Vause, Wagner, Wiethuechter   +78 more
core   +2 more sources

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Resolving systemic financial crisis : policies and institutions [PDF]

The authors analyze the role of institutions in resolving systemic banking crises for a broad sample of countries. Banking crises are fiscally costly, especially when policies like substantial liquidity support, explicit government guarantees on ...
Claessens,Constantijn A., Klingebiel, Daniela, Laeven, Luc   +2 more
core