Results 71 to 80 of about 7,269,468 (262)

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. [PDF]

, 2010
Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of
Seiderer, J., Seiderer Julia, Folwaczny, M., Ochsenkühn, Thomas, Fries, C., Beigel, F., Klein, Wolfram, Glas, J., Müller-Myhsok, B., Folwaczny Matthias, Darina Roeske, Matthias Folwaczny, Bertram Müller-Myhsok, Göke, Burkard, Jörg T Epplen, Epplen Jörg T., Diegelmann Julia, Fries Christoph, Melinda Nagy, Pfennig Simone, Brand, Stephan, Nagy, M., Göke, B., Brand Stephan, Nagy, Melinda, Thomas Ochsenkühn, Weidinger Maria, Beigel, Florian, Weidinger, Maria, Ochsenkühn, T., Klein, Wolfgang, Epplen, Jörg T., Julia Diegelmann, Beigel Florian, Müller-Myhsok Bertram, Göke, Burkhard, Fries, Christoph, Folwaczny, Matthias, Pfennig, S., Pfennig, Simone, Peter Lohse, Seiderer, Julia, Roeske, Darina, Glas, Jürgen, Epplen, J., Diegelmann, J., Lohse, P., Christoph Fries, Ochsenkühn Thomas, Müller-Myhsok, Bertram, Weidinger, M., Burkhard Göke, Göke Burkhard, Klein, W., Stephan Brand, Maria Weidinger, Roeske Darina, Brand, S., Jürgen Glas, Klein Wolfram, Roeske, D., Lohse, Peter, Diegelmann, Julia, Nagy Melinda, Simone Pfennig, Wolfram Klein, Glas Jürgen, Florian Beigel, Lohse Peter, Julia Seiderer   +69 more
core   +2 more sources

A Case With IgG4-Related Spinal Pachymeningitis Causing Spinal Cord Compression

Frontiers in Neurology, 2020
Immunoglobulin G4 (IgG4)-related disease is a systemic disease characterized by sclerosing lesions and an increased serum IgG4 level. This condition can involve any organ, but IgG4-related spinal pachymeningitis is relatively rare.
Rensheng Zhang, Jiguo Gao, Teng Zhao, Beilin Zhang, Chenglin Wang, Chao Wang, Lexiang Cui, Jiafeng Chen, Shaokuan Fang   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Review of Clinical Recommendations for Kawasaki Disease/Syndrome

Педиатрическая фармакология, 2017
The article presents the detailed key provisions of the clinical recommendations on providing medical care to children with Kawasaki syndrome/illness, developed by the professional association of pediatric specialists — the Union of Pediatricians of ...
Alexander A. Baranov, Leyla S. Namazova-Baranova, Vladimir K. Tatochenko, Elena N. Basargina, Maya D. Bakradze, Elena A. Vishneva, Liliia R. Selimzianova, Tatiana V. Kulichenko, Nato D. Vashakmadze, Grigoriy V. Revunenkov, Anastasiya S. Polyakova, Nataliya V. Fyodorova   +11 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Novel IL10 gene family associations with systemic juvenile idiopathic arthritis [PDF]

, 2006
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic childhood disability and encompasses a number of disease subgroups. In this study we have focused on systemic JIA (sJIA), which accounts for approximately 11% of UK JIA cases.
Woo, P, Samuel, JM, Gutierrez, Ana, Lewis, C M; id_orcid, Lewis, CM, Woo, Patricia, Samuel, J M, Fife, M S, Ogilvie, Emma M., Carmel JW Stock, Fife, MS, Lewis, Cathryn M., Emma M Ogilvie, Ogilvie, EM, Ana Gutierrez, Mack, LF, Fife, Mark S., Samuel, Jane M., Thomson, W, Cathryn M Lewis, Mark S Fife, Mack, L F, Mack, Lisa F., Ogilvie, E M, Gutierrez, A, Jane M Samuel, Stock, CJW, Stock, C J W, Stock, Carmel J W, Wendy Thomson, Thomson, Wendy, Patricia Woo, Lisa F Mack   +32 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Natural history and outcome in systemic AA amyloidosis [PDF]

, 2007
BACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders.
Goodman, HJB, Lachmann, HJ, Gillmore, JD, Hawkins, PN, Gilbertson, JA, Gallimore, JR, Sabin, CA   +6 more
core  

Discovery of a novel pathway for an SLE-related disease complex in the canine breed Nova Scotia duck tolling retriever [PDF]

, 2013
The dog is an excellent model to study inherited complex diseases, due to its unique population history and haplotype structure. In this thesis, dogs from the breed Nova Scotia duck tolling retriever (NSDTR) have been used as a model for defining the ...
Wilbe, Maria
core   +1 more source