Results 111 to 120 of about 362,549 (389)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Which Design and Biomaterial Factors Affect Clinical Wear Performance of Total Disc Replacements? A Systematic Review [PDF]
, 2014 Background Total disc replacement was clinically introduced to reduce pain and preserve segmental motion of the lumbar and cervical spine. Previous case studies have reported on the wear and adverse local tissue reactions around artificial prostheses ...
Alexander, Dominik D. +4 more
core +2 more sources
Scientific ReportsObesity is a prevalent health issue among adolescents, characterized by chronic low-grade inflammation, which increases the risk of developing various chronic diseases in the future.
Yu-zhen Zhang +11 more
semanticscholar +1 more source
Journal of Behçet Uz Children's HospitalObjective: Recent studies showed that Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI) can be used as inflammatory markers.
Betül Öztürk +10 more
doaj +1 more source
Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer [PDF]
, 2017 Introduction: The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer.
Horgan, Paul G. +6 more
core +2 more sources
Inflammation ResearchChronic kidney disease (CKD) is linked to immunity and inflammation. Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are novel measures for gauging an individual’s systemic inflammatory activity.
Peixian Huang +4 more
semanticscholar +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Frontiers in Public HealthBackgroundSedentary behavior (SB), has been closely linked to numerous detrimental health effects. While the individual and combined impacts of such behaviors on immune-inflammatory responses remain ambiguous, innovative indices like the Systemic Immune ...
Xian Wu +6 more
doaj +1 more source
Puberty: Is Your Gingiva Having Mood Swings? [PDF]
, 2019 Objectives/aim: The purpose of this paper is to explore the effects on the different pathological changes in the oral cavity due to puberty, in both males and females.
Connerley, Kendall A +1 more
core +1 more source