Results 41 to 50 of about 23,583 (209)

Mandatory Minimum Prison Sentencing and Systemic Racism

Osgoode Hall Law Journal, 2001
This article discusses the relationship between racist policing, the exercise of prosecutorial discretion, and the disproportionate imposition of mandatory prison sentences on Black-Canadians It argues that the retention and expansion of mandatory prison
Faizal R. Mirza
doaj   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Navigating racism: A scoping review of barriers in the experiences of Black Health Professions students

Discover Education
This manuscript examines the racism experienced by Black students in health professions through a scoping review of 33 articles. The analysis reveals significant gaps in the literature across multiple dimensions of racism, including interpersonal ...
Monica L. Miles, Terrell R. Morton, Philip Pettis, Ramar Henderson, Carl A. Frizell, Vanessa S. Bester, Aisha K. O’Mally, Logan Trevino-Fica   +7 more
doaj   +1 more source

Depicting the racist past in a "postracial" age: The white, male protagonist in Hell on Wheels and The Knick

Alphaville: Journal of Film and Screen Media, 2017
This article examines the ways in which depictions of race and racism in some prime-time historical dramas promote contemporary postracial ideologies. Focusing on the portrayals of overt racism and interracial relationships in Hell on Wheels (2011–2016 ...
Michael L. Wayne
doaj   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Anti-Black racism in library and information science curriculum

Partnership: The Canadian Journal of Library and Information Practice and Research
Canadian communities are facing a crisis of inequity, and library service providers must do more to respond to the causal conditions of anti-Black and other forms of systemic racism (Black & Mehra, 2023). Beginning in 2022, the first known Canadian MLIS
Amber Matthews
doaj   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

“You’re Good as Long as You’re Silent”

Critical Education
In this article, we re/present our research alongside Palestinian Muslim students and families in Albert, focusing on research participants’ experiences of anti-Palestinian racism in k-12 schooling.
Muna Saleh, Farid Saberi, Nada Awwad
doaj   +1 more source

The psychosocial toll of Dublin III on asylum seekers in the Netherlands

American Journal of Community Psychology, EarlyView.
Abstract The Dublin III Regulation determines which EU Member State is responsible for examining asylum claims, but its implementation carries significant consequences for those subjected to it. This study examines how Dublin III, as implemented in the Netherlands, affects asylum seekers' psychosocial wellbeing using Silove′s Adaptation and Development
Imen El Amouri
wiley   +1 more source