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Current Rheumatology Reports, 2001
Systemic scleroderma in children is very rare and is considered similar to adult-onset disease. In adults, new etiopathogenetic and therapeutic approaches have emerged in recent years. For instance, it has been shown that microchimerism could play a role in disease pathogenesis and that immunoablation followed by stem cell rescue could be of potential ...
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Systemic scleroderma in children is very rare and is considered similar to adult-onset disease. In adults, new etiopathogenetic and therapeutic approaches have emerged in recent years. For instance, it has been shown that microchimerism could play a role in disease pathogenesis and that immunoablation followed by stem cell rescue could be of potential ...
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Systemic scleroderma: a spatiotemporal clustering
Internal Medicine Journal, 2005AbstractBackground and aims: The aetiology of systemic scleroderma remains poorly understood. Twin studies suggest a low genetic input. Of the incriminated environmental agents, silica and vinyl chloride monomer exposure appear the most convincing. Spatiotemporal clustering has been demonstrated only three times previously.
Englert, H +7 more
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Journal of the American Academy of Dermatology, 1988
Systemic scleroderma is a generalized disease of connective tissue involving mainly the skin, the gastrointestinal tract, the lungs, the heart, and the kidneys. It can be present in different forms, of which acroscleroderma, with limited cutaneous and extracutaneous involvement, and diffuse scleroderma within a more rapid progression are most ...
Michael Meurer, Thomas Krieg
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Systemic scleroderma is a generalized disease of connective tissue involving mainly the skin, the gastrointestinal tract, the lungs, the heart, and the kidneys. It can be present in different forms, of which acroscleroderma, with limited cutaneous and extracutaneous involvement, and diffuse scleroderma within a more rapid progression are most ...
Michael Meurer, Thomas Krieg
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Progressive Systemic Sclerosis (Scleroderma)
New England Journal of Medicine, 1953THE skin manifestations of scleroderma have long been recognized and adequately described. These features are usually identified readily, particularly in the later phases of the disease when the spectacular, hardened, bound-down, wrinkleless appearance of the skin is so characteristic as to supply a descriptive name for the illness. This term refers to
Theodore B. Bayles +2 more
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Scleroderma-Inducing Glycosaminoglycan in the Urine of Patients with Systemic Scleroderma
Dermatology, 1978A glycosaminoglycan with scleroderma-inducing effect was isolated and partially purified from the urine of patients with systemic scleroderma. The glycosaminoglycan was an N-sulfated glycosaminoglycuronan and its high total sulfate and 2,5-anhydromannose contents suggest that the glycosaminoglycan is a degradation product of heparin or polysulfated ...
Hidekazu Ishikawa +3 more
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Mortality in Systemic Sclerosis (Scleroderma)
QJM: An International Journal of Medicine, 1992Two hundred and thirty-seven patients with systemic sclerosis were followed prospectively in a scleroderma clinic. The overall 3, 6, and 9-year survival rates were 86, 76 and 61 per cent respectively. Renal, cardiac and pulmonary disease, and older age at enrollment were adverse prognostic factors associated with reduced survival.
M Aubrey +9 more
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Systemic Sclerosis, Scleroderma
2006Abstract The scleroderma spectrum of disorders includes several diseases that have Raynaud’s phenomenon or skin sclerosis in common, comprising (1) localized cutaneous scleroderma; (2) systemic sclerosis (SSc)—the most important form of scleroderma—limited cutaneous SSc, diffuse cutaneous SSc, and overlap syndromes (with features of ...
Christopher P. Denton, Carol M. Black
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Progressive Systemic Sclerosis (Scleroderma)
Australasian Annals of Medicine, 1970SummarySixteen cases of progressive systemic sclerosis (PSS) were studied in a large general hospital in Singapore from 1957 to 1967. Thirteen were Chinese and 3 Malays. The majority were middle‐aged housewives and half of the cases were seen less than six months after onset.
Oon Teik Khoo, Chong Hai Tay
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Vitiligolike Macules in Systemic Scleroderma
Archives of Dermatology, 1983Changes of hyperpigmentation and depigmentation in systemic scleroderma have been known since the last century, but their relationship to the pathogenesis of the condition is poorly understood. Clinical, histologic, histochemical, immunopathologic, and electron microscopic studies of the depigmented lesions in seven patients with systemic scleroderma ...
Nestor P. Sanchez +2 more
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Erosive Arthropathy in Systemic Scleroderma
JAMA: The Journal of the American Medical Association, 1975ALTHOUGH the classic bony changes seen in systemic scleroderma may be accompanied by changes in the joints, only rarely is destruction of subchondral bone found in joint spaces. 1-3 However, roentgenograms of the hand of a 64-year-old woman with systemic scleroderma who was seen recently at the Lahey Clinic showed a classic pencil-in-cup (mortar and ...
William P. Beetham, Wayne Wild
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