Results 121 to 130 of about 307,381 (359)

Rethinking Strategies for a Pharmaceutical Approach to Pain Related to Connective Tissue–Related Raynaud Phenomenon in the United States

Arthritis Care &Research, EarlyView.
Objective There are no US Food and Drug Administration–approved therapies for Raynaud phenomenon (RP) in the United States. Clinical trials have been challenged by study design. Important advances in RP patient‐reported outcome measures and mechanistic quantification allow RP‐related pain characterization.
Tracy M. Frech, Charles G. Frech, W. David Merryman, Andrew Sternlicht, Justin Baba   +4 more
wiley   +1 more source

Mesenchymal stem cell as a novel approach to systemic sclerosis; current status and future perspectives

Cell Regeneration, 2020
Systemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelial cells, activation of immune responses, and progression of tissue fibrosis in the skin and various internal organs.
Mina Abedi, Sepideh Alavi-Moghadam, Moloud Payab, Parisa Goodarzi, Fereshteh Mohamadi-jahani, Forough Azam Sayahpour, Bagher Larijani, Babak Arjmand   +7 more
doaj   +1 more source

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]

, 2015
The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R, Beon M, Bryan N, Butterfield TA, Connolly MK, Desmoulière A, Fallowfield JA, Galván‐Peña S, Gordon S, Goumans M, Hu B, Ito T, Jimenez SA, Korns D, Krieg T, Lassen S, Lech M, Leibovich SJ, Lev B, Mantovani A, Mantovani A, Molumdar K, Nestle FO, O’Doherty U, Piera‐Velazquez S, Poland GA, Rafii R, Rigamonte E, Tacke F, Venbervliet B, Wang Y, Wick G, Wijesundera KK   +32 more
core   +2 more sources

Diagnostic Utility of Testing for Novel Murine Autoantibodies for Sjögren's Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, Accepted Article.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren's disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Lower-limb Ulcers in Systemic Sclerosis: A Multicentre Retrospective Case-control Study

Acta Dermato-Venereologica, 2018
Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes of lower-limb ulcers in systemic sclerosis patients and to assess factors associated with ischaemic causes (arterial ...
Gérôme Bohelay, Sophie Blaise, Pierre Levy, Antoine Claeys, Nathalie Baudot, Jean-Francois Cuny, Hervé Maillard, Florence Granel-Brocard, Thierry Boyé, Catherine Lok, Nathalie Bénéton, Camille Francès, Patricia Senet   +12 more
doaj   +1 more source

Influence of FK 506 (tacrolimus) on circulating CD4 ⁺ t cells expressing cd25 and cd45ra antigens in 19 patients with chronic progressive multiple sclerosis participating in an open label drug safety trial [PDF]

, 1994
We have taken the opportunity of a clinical trial of the potential efficacy and safety of FK 506 (tacrolimus) in chronic progressive multiple sclerosis (MS) to examine the influence of this potent new immunosuppressant on circulating T-lymphocytes in an ...
A. W. Thomson, Abu-Elmagd K., B. Eidelman, B. Lemster, Collett D, Eidelman B H., Ellison G W., Emry P., Fung J J., H. R. Rilo, Hafler D A., Hafler D A., Hauser S L., Hintzen R Q., Hofman F M., J. J. Fung, J. Woo, Japanese FK, K. Abu-Elmagd, Kino T., Kurtzke J F, L. L. Huang, Lebranchu Y., Lemster B., Lemster B., McCauley J., McMichael J., Mochizuki M., Mortimoto C, N. Johnson, P. B. Carroll, R. Russell-Hall, Rose L M., Starzl T E., T. E. Starzl, Tamura K., The Multiple Sclerosis Study Group, Thomson A V., Thomson A W, Thomson A W., Thomson A W., Thomson A W., Tocci M J., W. Irish, Woo J., Woo J., Zeevi A.   +46 more
core   +1 more source

Blood Neutrophil Count and Neutrophil‐to‐Lymphocyte Ratio for Prediction of Disease Progression and Mortality in Two Independent Systemic Sclerosis Cohorts

, 2022
Nancy Wareing, Vishnu Mohan, Rana Taherian, Elizabeth R. Volkmann, Marka A. Lyons, Holly Wilhalme, Michael D. Roth, Rosa M. Estrada‐Y‐Martin, Brian Skaug, Maureen D. Mayes, Donald P. Tashkin, Shervin Assassi   +11 more
openalex   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Comment on: a novel transition clinic structure for adolescent and young adult patients with childhood onset rheumatic disease improves transition outcomes

Pediatric Rheumatology Online Journal, 2022
Mislav Radić
doaj   +1 more source

Therapeutic Promise of Hyaluronidase in Systemic Sclerosis: A Systematic Review

Dermatology Practical & Conceptual
Introduction: Systemic sclerosis, also known as scleroderma, is a chronic disease marked by autoimmune-mediated damage to connective tissues leading to vascular damage, tissue injury, and fibrosis.
Anika Pulumati, Rachel Lin, Scott Elman
doaj   +1 more source