Results 121 to 130 of about 1,628,316 (351)
Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis
Nature CommunicationsSystemic sclerosis is a connective tissue disorder characterized by excessive fibrosis that primarily affects women, and can present as a multisystem pathology.
Sriram Vijayraghavan +7 more
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Systemic Sclerosis in Males—Deciphering the Enigma of Erasmus Syndrome
Indian Journal of DermatologyBackground: Systemic sclerosis is an autoimmune connective tissue disease characterized by fibrosis in skin and internal organs. Chronic exposure to silica may not only lead to silicosis of lungs but also systemic sclerosis.
Reena K. Sharma, Mudita Gupta
doaj +1 more source
Adie’s Tonic Pupil in Systemic Sclerosis: A Rare Association
Case Reports in Ophthalmological Medicine, 2015 We report a rare association of Adie’s tonic pupil in a patient with systemic sclerosis who was otherwise systemically stable. This paper is an effort to unravel whether the tonic pupil and systemic sclerosis are an association by chance (which may be ...
Anusha Venkataraman +2 more
doaj +1 more source
Prague Medical Report, 2020 Musculoskeletal system impairment is a major cause of functional alterations in subjects with systemic sclerosis. Autologous hematopoietic stem cell therapy (AHSCT) may have an important role in the treatment functional of systemic sclerosis patients ...
Thamyres Branco +8 more
doaj +1 more source
Nature Communications, 2019 Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify ...
E. López-Isac +41 more
semanticscholar +1 more source
Reumatismo, 2011 The treatment of the patient with systemic sclerosis has greatly improved in the last ten years, because of two kinds of achievements. A number of drugs have been demonstrated to be active in some disease manifestations like alveolitis, pulmonary hypertension and complicated Raynaud's phenomenon. Some of these drugs namely cyclophosphamide and iloprost
openaire +5 more sources
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy [PDF]
, 2017 BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis ...
Afeltra, Antonella M. Vittoria +7 more
core +1 more source
Annals of Occupational and Environmental Medicine, 2017 Background Occupational exposure to crystalline silica is a potential risk factor for various systemic autoimmune diseases including systemic sclerosis.
Jae Yoon Kim +7 more
doaj +1 more source
Advanced Science, EarlyView.This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo +10 more
wiley +1 more source