Results 151 to 160 of about 311,988 (356)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Periodontal health status in systemic sclerosis patients: Systematic review and meta-analysis.

PLoS ONE
ObjectiveThe present systematic review and meta-analysis aimed to evaluate the periodontal health of systemic sclerosis patients compared with non-systemic sclerosis controls.Materials and methodsOnline databases were searched for eligible studies on ...
Stefan Sredojevic, Dejana Colak, Rok Gaspersic, Slavica Pavlov Dolijanovic, Aleksandar Jakovljevic, Natasa Nikolic-Jakoba   +5 more
doaj   +1 more source

Troponin elevation independently associates with mortality in systemic sclerosis.

, 2022
Julie J. Paik, Deborah Y. Choi, Monica Mukherjee, Steven Hsu, Fredrick M. Wigley, Ami A. Shah, Laura K. Hummers   +6 more
openalex   +2 more sources

Systemic Sclerosis [PDF]

Journal of the Royal College of Physicians of London, 1968
openaire   +2 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

IgG from patients with systemic sclerosis bind to DNA antitopoisomerase 1 in normal human fibroblasts extracts

Biologics: Targets & Therapy, 2008
Mathieu C Tamby1, Amélie Servettaz1, Nicolas Tamas1, Joseph Reinbolt2, Frédéric Caux3, Olivier Meyer4, Yannick Allanore5, André Kahan5, Loïc Guillevin6, Luc Mouthon1,61Paris-Descartes University ...
Mathieu C Tamby, Amélie Servettaz, Nicolas Tamas, Joseph Reinbolt, Frédéric Caux, et al   +5 more
doaj  

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Long-term follow-up after autologous adipose-derived stromal vascular fraction injection into fingers in systemic sclerosis patients

, 2016
Aurélie Daumas, Jérémy Magalon, Élisabeth Jouve, Romain Truillet, Dominique Casanova, Laurent Giraudo, Julie Véran, A. Benyamine, Françoise Dignat‐George, G. Magalon, Florence Sabatier, B. Granel   +11 more
openalex   +2 more sources

Low influenza vaccination rate among patients with systemic sclerosis [PDF]

, 2009
Luc Mouthon, C Mestre, A. Bérezné, Serge Poiraudeau, C. Janssen, Philippe Guilpain, Loı̈c Guillevin, Odile Launay   +7 more
openalex   +1 more source