Results 141 to 150 of about 4,055,022 (317)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Level of Meaning: Systems of Property Relationships in Minangkabau [PDF]
, 1979 Franz von Benda‐Beckmann
openalex +1 more source
Effect of three tillage systems, levels of plant residues and type of crop on some physical properties and organic carbon fractions in a gypsiferous soil [PDF]
, 2021 H.A.S. Jeghata, N. Muhawish
openalex +1 more source
A hybrid methodology to enable the verification of temporal properties as system-level
, 2019 SoCs haben unterschiedliche Komplexitätsgrade und zudem werden kommende Generationen zunehmend komplexer. Allerdings bedeutet diese Zunahme an Komplexität und Funktionalität auch, dass die Lücke zwischen der Entwicklung des Designs und die Notwendigkeit der Verifizierung desselben immer größer wird.
openaire +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
INFLUENCE OF VARIATIONS OF THE PERIOD OF SAMPLING ON THE PROPERTIES OF DIGITAL CONTROL SYSTEMS
Вестник Кемеровского государственного университета, 2013 Effect of changes in sampling period on functional properties of digital control systems analyzes on the qualitative level by authors of the article. Filtering algorithms of discrete signals, that allows to increase reliability of measuring information ...
V. Y. Kartashov, S. S. Samoilenko
doaj
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Research Advances for Protein-Based Pickering Emulsions as Drug Delivery Systems
PharmaceuticsNanotechnologically engineered protein-based carriers have attracted considerable attention in the pharmaceutical field due to the advantages of superior biocompatibility, tunability and good emulsifying properties.
Long Deng +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source