Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering Protein Stability with Small Molecules: A Review of the ecDHFR Destabilizing Domain System. [PDF]
ACS Chem BiolRuhinda M, Olmo RP, Burini BC.
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Optimizing phage therapy with antidefense proteins acquired from the environment. [PDF]
Front MicrobiolDas R.
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Sustainable Design Reuse: Integrating Biomimicry and Parametric Thinking in Architectural Education. [PDF]
Biomimetics (Basel)Semlali A, Tamzini S, Cazacova L.
europepmc +1 more source
Inducible CRISPR/Cas systems in precision oncology: Current applications and future perspectives. [PDF]
Clin Transl MedDing Z, Wei Y, Han Y, Gu P.
europepmc +1 more source
Strengthening women's leadership in health systems through innovation and intersectionality. [PDF]
Int J Equity HealthOsborne A, Vandi M.
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Irrational System Behavior in a System of Systems
2018 13th Annual Conference on System of Systems Engineering (SoSE), 2018System of systems (SoS) failures can sometimes be traced to a system within the SoS behaving in unexpected ways. Due to their emergent complexity, these types of failures are notoriously challenging to foresee. This paper presents a method to aid in predicting unknown unknowns in a SoS. Irrationality initiators – failure flows emanating from one system
Douglas L. Van Bossuyt +2 more
openaire +2 more sources