Results 221 to 230 of about 32,758,152 (295)

Too dim, too bright, and just right: Systems analysis of the Chlamydomonas diurnal program under limiting and excess light. [PDF]

Plant Cell
Dupuis S, Ojeda V, Gallaher SD, Purvine SO, Glaesener AG, Ponce R, Nicora CD, Bloodsworth K, Lipton MS, Niyogi KK, Iwai M, Merchant SS.   +11 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Primary oral healthcare in Ireland: a health systems analysis of publicly funded contracted services delivered by the general dental practitioner workforce. [PDF]

BMC Health Serv Res
Leavy P, Fleming P, Daly B, Barry S, Burke S.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Stressors contributing to burnout among acute care and trauma surgery care teams: a systems-analysis approach. [PDF]

Trauma Surg Acute Care Open
Kwong E, Adapa K, Goodacre V, Vizer L, Ra J, Greenberg C, Ivester T, Charguia N, Marks LB, Mazur L.   +9 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Systems analysis and improvement to optimize opioid use disorder care quality and continuity for patients exiting jail (SAIA-MOUD). [PDF]

Implement Sci
Gimbel S, Basu A, Callen E, Flaxman AD, Heidari O, Hood JE, Kellogg A, Kern E, Tsui JI, Turley E, Sherr K.   +10 more
europepmc   +1 more source

Stabilizing time-lagged climate impacts requires net-negative emissions for centuries

Environmental Research Letters
Johannes Bednar, Artem Baklanov, Justin Macinante, Jim W Hall, Thomas Gasser, Michael Obersteiner   +5 more
doaj   +1 more source

Access to childhood cancer medicines in South Africa: a health systems analysis of barriers and enablers. [PDF]

J Pharm Policy Pract
Joosse IR, van den Ham HA, Mantel-Teeuwisse AK, Perumal-Pillay VA, Suleman F.   +4 more
europepmc   +1 more source