Results 221 to 230 of about 34,801,835 (296)

Systems analysis unravels a common rural-urban gradient in immunological profile, function, and metabolic dependencies. [PDF]

Sci Adv
Manurung MD, Heieis GA, König M, Azimi S, Ndao M, Veldhuizen T, Hoving D, Hoekstra PT, Kruize YCM, Wammes LJ, Menafra R, Cisse M, Mboup S, Dieye A, Kloet S, Tahapary DL, Supali T, Wuhrer M, Hokke CH, Everts B, Mahfouz A, Jochems SP, Yazdanbakhsh M, Mbow M.   +23 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Systems analysis of long-term heat stress responses in the C4 grass Setaria viridis. [PDF]

Plant Cell
Zhang P, Sharwood RE, Carroll A, Estavillo GM, von Caemmerer S, Furbank RT.   +5 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Changing temporal patterns in patient-reported wish to live and wish to die signal the imminent emergence and aftermath of suicide attempts: a dynamical systems analysis. [PDF]

BMC Psychiatry
Bryan CJ, Bozzay ML, Hay J, Starkey A, Tabares JV, Baker JC.   +5 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A resuscitation systems analysis for South Africa: A narrative review. [PDF]

Resusc Plus
van Rensburg L, Majiet N, Geldenhuys A, King LL, Stassen W.   +4 more
europepmc   +1 more source

Stabilizing time-lagged climate impacts requires net-negative emissions for centuries

Environmental Research Letters
Johannes Bednar, Artem Baklanov, Justin Macinante, Jim W Hall, Thomas Gasser, Michael Obersteiner   +5 more
doaj   +1 more source

Too dim, too bright, and just right: Systems analysis of the Chlamydomonas diurnal program under limiting and excess light. [PDF]

Plant Cell
Dupuis S, Ojeda V, Gallaher SD, Purvine SO, Glaesener AG, Ponce R, Nicora CD, Bloodsworth K, Lipton MS, Niyogi KK, Iwai M, Merchant SS.   +11 more
europepmc   +1 more source