Results 41 to 50 of about 13,108,811 (339)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Global resource potential of seasonal pumped hydropower storage for energy and water storage

Nature Communications, 2020
The potential of seasonal pumped hydropower storage (SPHS) plant to fulfil future energy storage requirements is vast in mountainous regions. Here the authors show that SPHS costs vary from 0.007 to 0.2 US$ m−3 of water stored, 1.8 to 50 US$ MWh−1 of ...
Julian D. Hunt, Edward Byers, Yoshihide Wada, Simon Parkinson, David E. H. J. Gernaat, Simon Langan, Detlef P. van Vuuren, Keywan Riahi   +7 more
doaj   +1 more source

Global anthropogenic emissions of particulate matter including black carbon [PDF]

Atmospheric Chemistry and Physics, 2017
This paper presents a comprehensive assessment of historical (1990–2010) global anthropogenic particulate matter (PM) emissions including the consistent and harmonized calculation of mass-based size distribution (PM1, PM2. 5, PM10), as well as primary
Z. Klimont, K. Kupiainen, K. Kupiainen, C. Heyes, P. Purohit, J. Cofala, P. Rafaj, J. Borken-Kleefeld, W. Schöpp   +8 more
doaj   +1 more source

Reliability Analysis of Concurrent Systems using LTSA [PDF]

, 2007
The analysis for software dependability is considered an important task within the software engineering life cycle. However, it is often impossible to carry out this task due to the complexity of available tools, lack of expert personnel and time-to ...
Rodrigues, GN, Rosenblum, DS, Wolf, J
core   +1 more source

Negative emissions to mitigate Earth system risks

Nature Communications
Most climate policies are designed under a deterministic Earth system and their climate implications evaluated ex-post. Approaches that incorporate uncertainty ex-ante to anticipate Earth system risks remain underexplored.
Thomas Gasser, Armon Rezai, Côme Cheritel, Artem Baklanov, Michael Obersteiner   +4 more
doaj   +1 more source

BRST analysis of general mechanical systems

, 2013
We study the groups of local BRST cohomology associated to the general systems of ordinary differential equations, not necessarily Lagrangian or Hamiltonian.
A.A. Sharapov, Agrachev, Alexandrov, Barnich, Barnich, Barnich, Barnich, Barnich, Barnich, Batalin, Cattaneo, D.S. Kaparulin, Fuchs, Grigoriev, Henneaux, Henneaux, Kaparulin, Kaparulin, Kazinski, Kosmann-Schwarzbach, Lada, Lyakhovich, Lyakhovich, Lyakhovich, Lyakhovich, Maclane, Retakh, S.L. Lyakhovich, Seiler, Voronov   +29 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Causal Loop Diagramming of Socioeconomic Impacts of COVID-19: State-of-the-Art, Gaps and Good Practices

Systems, 2021
The complexity, multidimensionality, and persistence of the COVID-19 pandemic have prompted both researchers and policymakers to turn to transdisciplinary methods in dealing with the wickedness of the crisis.
Nikita Strelkovskii, Elena Rovenskaya
doaj   +1 more source

Computer-aided analysis of concurrent systems [PDF]

, 1985
The introduction of concurrency into programs has added to the complexity of the software design process. This is most evident in the design of communications protocols where concurrency is inherent to the behavior of the system. The complexity exhibited
Morgan, E. Timothy, Razouk, Rami R.
core   +1 more source

Phase Analysis of MIMO LTI Systems

, 2019
In this paper, we introduce a definition of phase response for a class of multi-input multi-output (MIMO) linear time-invariant (LTI) systems, the frequency responses of which are cramped at all frequencies.
Chen, Wei, Khong, Sei Zhen, Qiu, Li, Wang, Dan   +3 more
core   +1 more source