Results 201 to 210 of about 2,460,905 (269)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Building trust in clinical research: a systems approach to ethical engagement and sustainable outcomes. [PDF]

Front Pharmacol
Blom JMC, Rivi V, Tascedda F, Pani L.
europepmc   +1 more source

Health Systems Approach to Strengthen Rehabilitation. [PDF]

Acta Med Philipp
Carlos FAB.
europepmc   +1 more source

Systems approach identifies monocyte imbalance in symptomatic and asymptomatic P. vivax malaria. [PDF]

Mol Syst Biol
Studniberg SI, Bafit M, Ioannidis LJ, Worley MJ, Trianty L, Utami RAS, Puspitasari AM, Apriyanti D, Coutrier FN, Poespoprodjo JR, Kenangalem E, Andries B, Prayoga P, Price RN, Noviyanti R, Garnham AL, Hansen DS.   +16 more
europepmc   +1 more source

Metabolic Reprogramming Through Polyphenol Networks: A Systems Approach to Metabolic Inflammation and Insulin Resistance. [PDF]

Med Sci (Basel)
Shimu SJ, Mahir JUK, Shakib FAF, Ridoy AA, Samir RA, Jahan N, Hasan MF, Sazzad S, Akter S, Mohiuddin MS, Shawon MJA, Shariare MH, Mohib MM, Uddin MB.   +13 more
europepmc   +1 more source

A Systems Approach to Homeostasis: What Euryhaline Fish Teach Us About Organismal Stress Responses. [PDF]

Integr Comp Biol
Mauro AA, Velotta JP, Ghalambor CK.
europepmc   +1 more source