Results 291 to 300 of about 2,957,126 (345)

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment. [PDF]

PLoS One
Sanami S, Aghaamoo S, Ahmad S, Fazli A, Mansouri B, Nobre Oliveira JI, Rahmanian M.   +6 more
europepmc   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF. [PDF]

JACC Basic Transl Sci
Gibb AA, LaPenna K, Gaspar RB, Latchman NR, Tan Y, Choya-Foces C, Doiron JE, Li Z, Xia H, Lazaropoulos MP, Conwell M, Sharp TE, Goodchild TT, Lefer DJ, Elrod JW.   +14 more
europepmc   +1 more source

Mapping physiology: A systems biology approach for the development of alternative methods in toxicology

Bernard Staumont, Luiz Carlos Maia Ladeira, A. Gamba, Harm J. Heusinkveld, Aldert H. Piersma, Ellen Fritsche, Rosalinde Masereeuw, Tamara Vanhaecke, Marc Teunis, T. Luechtefeld, Thomas Härtung, Ramiro Jover, Mathieu Vinken, Liesbet Geris   +13 more
openalex   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Systems Biology and Functional Assessments of Human iPSC-Cardiomyocyte Models of Insulin Resistance Capture Key Hallmarks of Diabetic Cardiomyopathy. [PDF]

Diabetes
Carter RD, Purnama U, Castro-Guarda M, Montes-Aparicio CN, Chandran A, Mbasu R, Ruby M, Daly C, Brisk K, Christian HC, Miller JJJJ, Buffa FM, Heather LC, Carr CA.   +13 more
europepmc   +1 more source

Artemisinin derivatives modulate KEAP1-NRF2-xCT pathway to alleviate Sjögren's disease: insights from scRNA-seq and systems biology. [PDF]

Front Immunol
Luo Y, Zeng L, Wang Y, Yang Q, Liu C, Tang X, Yao G, Sun L.   +7 more
europepmc   +1 more source

From Parts to Whole: A Systems Biology Approach to Decoding Milk Fever. [PDF]

Vet Sci
Ametaj BN.
europepmc   +1 more source