Results 291 to 300 of about 2,989,026 (346)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review. [PDF]

EBioMedicine
Elbatarny M, Lu YT, Hu M, Coles J, Mital S, Ross-White A, Honjo O, Barron DJ, Gramolini AO.   +8 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Systems biology analysis of long non-coding RNAs and targets to identify key modules and biomarkers in breast cancer. [PDF]

Discov Oncol
Ma C, Zhang X, Zhang R, Yang H, Wang J, Li C.   +5 more
europepmc   +1 more source

Supplementary Figure S4 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer

Annabelle Nwaokorie, Walter Kölch, Dirk Fey   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

New insights into translational research in Alzheimer's disease guided by artificial intelligence, computational and systems biology. [PDF]

Acta Pharm Sin B
Jiang S, Tian Z, Yang Y, Li X, Zhou F, Cheng J, Lyu J, Gao T, Zhang P, Han H, Tong Z.   +10 more
europepmc   +1 more source

Supplementary Figure S8 from A Systems Biology Approach to Understand the Racial Disparities in Colorectal Cancer

Annabelle Nwaokorie, Walter Kölch, Dirk Fey   +2 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source