Results 131 to 140 of about 39,699,316 (287)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Host R-M Systems Change the Host Range of Staphylococcus Phage EBHT. [PDF]

Microbiologyopen
Tuomala H, Holtel J, Markkanen M, Patpatia S, Kaansalo K, Rolland C, Bayfield OW, Ranta K, Skurnik M, Wittmann J, Kiljunen S.   +10 more
europepmc   +1 more source

Effects of the First 1000 Days Program, a systems-change intervention, on obesity risk factors during pregnancy. [PDF]

BMC Pregnancy Childbirth, 2021
Simione M, Moreno-Galarraga L, Perkins M, Price SN, Luo M, Kotelchuck M, Blake-Lamb TL, Taveras EM.   +7 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Moving Beyond Diversity: Using Critical Race Theory and Black Feminist Thought to Foster Black Inclusion Through Undergraduate University Admissions

Atlantis
This paper argues that concrete actions are needed to address anti-Black racism and foster Black inclusion in Canadian higher education. These pertinent actions should target the systemic barriers faced by Black students when accessing post-secondary ...
Christopher Stuart Taylor, Grace A. Gomashie   +1 more
doaj  

From Signal to Systems Change: The Convergence of Epidemiology and Implementation Science in Precision Cardiovascular Medicine. [PDF]

Circ Popul Health Outcomes
Farmer N, Gonzalez Casanova I, Brownson RC, Powell-Wiley TM.   +3 more
europepmc   +1 more source

The Inclusive Professional Framework for Societies: Changing Mental Models to Promote Diverse, Equitable, and Inclusive STEM Systems Change. [PDF]

Front Sociol, 2021
Leibnitz GM, Gillian-Daniel DL, Greenler RMCC, Campbell-Montalvo R, Metcalf H, Segarra VA, Peters JW, Patton S, Lucy-Putwen A, Sims EL.   +9 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Facilitating food security systems change in regional Australia through a strengths-based, co-design process. [PDF]

Health Promot Int
Chiera I, Doe J, Stoneham M, Devine A, Godrich SL.   +4 more
europepmc   +1 more source

Navigating the river(s) of systems change: a multi-methods, qualitative evaluation exploring the implementation of a systems approach to physical activity in Gloucestershire, England. [PDF]

BMJ Open, 2022
Nobles J, Fox C, Inman-Ward A, Beasley T, Redwood S, Jago R, Foster C.   +6 more
europepmc   +1 more source