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The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

open access: yesFEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji   +3 more
wiley   +1 more source
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Agile Systems Engineering

ATZelectronics worldwide, 2021
There is no software without systems engineering. Software is always part of a bigger system. Even a simple application interacting with a human user consists of software building blocks, a service delivery, various hardware systems, user experience, energy management, connectivity and many more.
Christof Ebert, Frank Kirschke-Biller
openaire   +2 more sources

System of systems engineering

IEEE Engineering Management Review, 2003
The purpose of this article is to develop the concept, foundations, research directions, and practice implications for System of Systems Engineering (SoSE).
Ghaith Rabadi   +7 more
openaire   +3 more sources

Engineering Systems of Systems

2008 2nd Annual IEEE Systems Conference, 2008
Over the past decade, the focus of much effort in systems development has evolved from the development of individual self- contained systems to the integration of large-scale systems of systems (SoS) that are constantly evolving to address new user needs.
Patrick R. H. Place   +5 more
openaire   +2 more sources

Systems engineering and management

Information Knowledge Systems Management, 2009
This chapter offers a systems view of healthcare delivery and outlines a wide range of concepts, principles, models, methods and tools from systems engineering and management that can enable the transformation of the dysfunctional “as is” healthcare system to an agreed-upon “to be” system that will provide ...
W. Dale Compton, William B. Rouse
openaire   +3 more sources

An implementers' view of systems engineering for systems of systems

2011 IEEE International Systems Conference, 2011
This has presented a time-sequenced wave model representation of SoS SE that is usable by SoS SE practitioners in developing implementation approaches to their activities. It has identified information critical to decision-making in SoS evolution, noted the artifacts in which the information is normally contained, and where the information and ...
George Rebovich   +4 more
openaire   +3 more sources

The Systems Engineering

2017
Many definitions of the Systems Engineering are proposed, and analyzing some differences between them help to highlight contents and open issues, as they are described in this chapter. Nevertheless, a short historical outline could be helpful in appreciating some characteristics of this methodology, which are even more detailed by a wide literature ...
Ambra Cala   +3 more
openaire   +2 more sources

SYSTEMS ENGINEERING VERSUS SYSTEMS ENGINEERS

INCOSE International Symposium, 1993
AbstractThe relationship between systems engineering and the engineering profession of Systems Engineer is poorly understood. This lack of understanding is one of the major factors contributing to the confusion and complexity associated with developing a common understanding of systems engineering in industry and academia.
openaire   +2 more sources

Towards Intelligence-Based Systems Engineering and System of Systems Engineering

2011
This introductory chapter defines intelligence-based systems with focus on semantic systems, simulation systems, and intelligent agents. Semantic systems define the foundation to communicate systems engineering challenges using logic, simulation systems introduce the dynamic component, and intelligent agents can introduce alternatives roles.
Charles B. Keating   +2 more
openaire   +2 more sources

Engineering in complex systems

Current Opinion in Biotechnology, 2010
The implementation of the engineering design cycle of measure, model, manipulate would drastically enhance the success rate of biotechnological designs. Recent progress for the three elements suggests that the scope of the traditional engineering paradigm in biotechnology is expanding.
Matthias Bujara, Sven Panke
openaire   +3 more sources

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