Results 191 to 200 of about 1,597,830 (316)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Biotechnology systems engineering: preparing the next generation of bioengineers. [PDF]

Front Syst Biol
Espinel-Ríos S.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Assessing Health Care Professionals' Perceptions of a New System in Clinical Workflows: Systems Engineering Initiative for Patient Safety-Based Consensual Qualitative Research. [PDF]

J Med Internet Res
Park YE, Ock M, Lee JH, Ko DH, Lee HJ, Park T, Yoo J, Lee Y.   +7 more
europepmc   +1 more source

Systems engineering-based framework of process risks in perioperative medication delivery. [PDF]

Br J Anaesth, 2022
Coppola SM, Neyens DM, Catchpole K, Gurses AP, Osei P, Biro JM, Alfred M, Rucks M, Tobin CD, Jaruzal C, Abernathy JH, Operating Room System based Medication Administration error Reduction Team (OR SMART) Research Group.   +11 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

C-5A Galaxy Systems Engineering Case Study

, 2008
The C-5 Systems Engineering Case Study captures the untold story of the application of systems engineering during the concept exploration, development, and production of the USAF C-5A and C-5B aircraft.
Air Force Center for Systems Engineering, Griffin, John M.   +1 more
core  

The complexity of safety: Embracing systems engineering in radiation oncology. [PDF]

J Appl Clin Med Phys
Wong LM, Pawlicki T.
europepmc   +1 more source

"We should be resourcing their liberation:" a qualitative formative study to guide introduction of a systems engineering intervention at a King County, WA juvenile detention center clinic. [PDF]

BMC Health Serv Res, 2023
Borges M, Schipper L, Gonzalez G, Goode S, Hersh D, Pham DQ, Kaplan B, Ronen K, Sherr K, Gimbel S.   +9 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source