Results 221 to 230 of about 4,654,755 (329)

GENESIS, a knowledge-based genetic engineering simulation system for represntation of genetic data and experiment planning [PDF]

, 1982
Peter Friedland, Larry Kedes, Douglas L. Brutlag, Yumi Iwasaki, René Bach   +4 more
openalex   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Relationships between physical characteristics of the pig house, the engineering and control systems of the environment, and production parameters of growing pigs [PDF]

, 1985
R. Geers, Daniël Berckmans, V. Goedseels, Alfons Maes, J Soontjens, Jeroen Mertens   +5 more
openalex   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Engineering feasibility study on automated attack-effects information systems. Final report

, 1973
F. M. Glass, J.M. Rochelle, Heather Wilson   +2 more
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Research and analysis of traction converter for EMU based on MBSE

机车电传动
This paper focuses on applying model-based systems engineering (MBSE) methodology to the design of EMU traction converters, to address challenges stemming from an abundance of information and complexities in modification.
WANG Baomin, YANG Jiuhe, ZHOU Jinxiang, WANG Haifang, CHE Jun   +4 more
doaj  

Model-Based Systems Engineering Applied to Trade-Off Analysis of Wireless Power Transfer Technologies for Implanted Biomedical Microdevices. [PDF]

Sensors (Basel), 2021
Martínez Rojas JA, Fernández JL, Sánchez Montero R, López Espí PL, Diez-Jimenez E.   +4 more
europepmc   +1 more source

Use of software engineering techniques in the design of the ALEPH data acquisition system [PDF]

, 1987
T. Charity, Richard McClatchey, J. Harvey   +2 more
openalex   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source