Results 221 to 230 of about 25,134,561 (338)

Philosophy on Safety of a Large System(Safety and Reliability in Mechanical Engineering -Philosophy and Technology)

, 1987
Jiro Kondo
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Using a Systems Engineering Approach to Build a PCR Testing System at a Medical School During the COVID-19 Pandemic. [PDF]

Risk Manag Healthc Policy
Oba J, Toriya M, Uwamino Y, Matsuo K.
europepmc   +1 more source

Electron-beam-controlled gas lasers: discussion from the engineering viewpoint. Part II. Problems in the electrical design of very high energy systems

, 2016
K B Riepe
openalex   +1 more source

THE IMPORTANCE OF DIGITAL TECHNOLOGIES IN TEACHING ENGINEERING COMPUTER GRAPHICS THROUGH THE PTS (PROFESSIONAL TECHNOLOGY SYSTEM) PLATFORM

J.Z. Tojiboyev, U.N. Ismatova
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Engineering development of advanced coal-fired low-emissions boiler system. Phase II subsystem test design and plan - an addendum to the Phase II RD & T Plan

, 1995
Babcock and Wilcox Co., Allison, OH (United States)
openalex   +2 more sources

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Engineering development of coal-fired high-performance power systems. Fourth quarterly report, 1996

, 1997
NONE
openalex   +2 more sources