Results 261 to 270 of about 1,597,830 (316)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Using Systems Engineering and Implementation Science to Design an Implementation Package for Preoperative Comprehensive Geriatric Assessment Among Older Adults Having Major Abdominal Surgery: Protocol for a 3-Phase Study. [PDF]

JMIR Res Protoc
Berian JR, Schwarze ML, Werner NE, Mahoney JE, Shah MN.   +4 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Nurses' preferences for interventions to improve infection prevention and control behaviors based on systems engineering initiative to patient safety model: a discrete choice experiment. [PDF]

BMC Nurs
Zhou Q, Liu J, Zheng F, Wang Q, Zhang X, Li H, Tan L, Luo W.   +7 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

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Engineering complex systems: implications for research in systems engineering

IEEE Transactions on Systems, Man and Cybernetics, Part C: Applications and Reviews, 2003
A discussion of the scope of systems engineering, which seems to cover everything and therefore, in a way, to cover nothing. Systems engineering crosses the boundaries of other disciplines. It is the exploration, understanding, and design of how everything fits together.
W B Rouse
exaly   +2 more sources

Agile Systems Engineering

ATZelectronics worldwide, 2021
There is no software without systems engineering. Software is always part of a bigger system. Even a simple application interacting with a human user consists of software building blocks, a service delivery, various hardware systems, user experience, energy management, connectivity and many more.
Christof Ebert, Frank Kirschke-Biller
openaire   +1 more source

System of systems engineering

IEEE Engineering Management Review, 2003
The purpose of this article is to develop the concept, foundations, research directions, and practice implications for System of Systems Engineering (SoSE).
Charles Keating, Ralph Rogers, Resit Unal, David Dryer, Andres Sousa-Poza, Robert Safford, William Peterson, Ghaith Rabadi   +7 more
openaire   +1 more source

KI-Engineering - AI Systems Engineering

Autom., 2022
KI-Engineering - im Langnamen KI Systems Engineering - beschreibt die Entwicklung einer neuen Ingenieurspraxis im Schnittpunkt von Systems Engineering und Künstlicher Intelligenz. Ziel ist es, die Anwendung von KI-Methoden im Kontext komplexer Entwicklungsprojekte zu professionalisieren.
Julius Pfrommer, Thomas Usländer, Jürgen Beyerer   +2 more
openaire   +1 more source