Results 231 to 240 of about 12,378,837 (298)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Secondary Use of Health Data in Canada and the European Union: Expectations, Frictions and the Politics of Scale. [PDF]

Sociol Health Illn
Donia J, Marelli L.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Engineering Framework for Intelligent Vision Inspection Systems (EF-IVIS): A Systems Engineering Methodology. [PDF]

Sensors (Basel)
Rysiński J, Jancarczyk D.
europepmc   +1 more source

Advanced Electronic Packaging Technologies: A Comparative Review of Architectures, Applications, Reliability. [PDF]

Micromachines (Basel)
Huang Y, Wang D, Li Q, Pan Z.
europepmc   +1 more source

A Conceptual Framework for 4D Holographic Visualization in Gastrointestinal Endoscopy: Toward Externalized Spatiotemporal Cognition. [PDF]

JMIR XR Spat Comput
Yamaguchi H, Fukuzawa M, Kawai T, Yamanishi F, Muramatsu T, Ichimiya T, Kagawa Y, Uchida K, Madarame A, Morise T, Yamauchi Y, Kono S, Naito S, Itoi T.   +13 more
europepmc   +1 more source

Low-Density Materials for Particle Accelerator Applications: Challenges, Capabilities, and Future Directions. [PDF]

Materials (Basel)
Lunt AJG, Sena-Welker E, Pasquino C, Poulin P, Sapinski M, Sgobba S, Stora T, Veness R.   +7 more
europepmc   +1 more source

Programmable RNA-Guided DNA Recombination: Mechanisms, Engineering, and Applications. [PDF]

Biomedicines
Ali Agha ASA, Hattab D, Bakhtiar A, Al Khatib AO, Abushahla HS, Alketbi S, Akour A.   +6 more
europepmc   +1 more source