Results 151 to 160 of about 110,790 (301)

Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting

open access: yesAdvanced Science, EarlyView.
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang   +6 more
wiley   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

open access: yesAdvanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang   +21 more
wiley   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

open access: yesAdvanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong   +12 more
wiley   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

open access: yesAdvanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang   +13 more
wiley   +1 more source

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