Results 31 to 40 of about 167,068,768 (221)

The Existence and Uniqueness of the Solution of a Nonlinear Partial Differential Equation in the Eontinuous Functions of Holder and Sobolev Spaces

پژوهش‌های ریاضی, 2020
Introduction Complex analysis is a comparatively active branch in mathematics which has grown significantly. A deep look at the implications of continuity, derivative and integral in complex analysis and their relation with partial differential equations
Mozhgan Akbari, Fateme Joveini
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Reproducing Kernel Hilbert Space Method for Solving System of Linear Weakly Singular Volterra Integral Equations

JOURNAL OF ADVANCES IN MATHEMATICS, 2018
The exact solutions of a system of linear weakly singular Volterra integral equations (VIE) have been a difficult to find.  The aim of this paper is to apply reproducing kernel Hilbert space (RKHS) method to find the approximate solutions to this type of systems. At first, we used Taylor's expansion to omit the singularity.  From an expansion the given
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

TRANSVERSE BENDING OF A THIN PERFORATED PLATE WEAKENED BY RECTILINEAR CRACKS WITH END ZONES OF PLASTIC DEFORMATION

Structural Mechanics of Engineering Constructions and Buildings, 2016
We give a problem solution for transverse bending of a thin plate, clamped at holes edges and weakened by doubly periodic system of rectilinear through cracks with unequal length, collinear to abscissa and ordinate axes plastic end zones.
B B Kazbekov
doaj  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A Spectral Method Based on Hahn Polynomials for Numerical Solution of Fractional Integro-Differential Equations with Weakly Singular Kernel

پژوهش‌های ریاضی, 2020
Introduction Despite wide applications of constant order fractional derivatives, some systems require the use of derivatives whose order changes with respect to other parameters.
Farideh Salehi, Habibollah Saeedi, Mahmoud Mohseni Moghadam   +2 more
doaj  

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source